Project 1 | Title: Therapeutic RNAi targeting CKIP-1 to reverse severe postmenopausal osteoporosis Principal Investigator: Prof.Ge Zhang (M.D.) Funding Body: Hong Kong General Reserch Fund Project ID: HKBU479111 Exercise Year: 2011/2012 Approved Project Duration: 30 months Project Fund: HK$ 920,000 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 2 | Title: Skeletal role of CK2-interating Protein-1 in Regulating Osteoblastic Bone Formation: Molecular Mechanism and Reversing Osteoporosis Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Research Grants Council & Natural Science Foundation Council Project ID: N_HKBU435/12 Exercise Year: 2012/2013 Approved Project Duration: 48 months Project Fund: HK$ 753,925 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 3 | Title: Study on molecular mechanism of bone formation reduction in aged women: Functional role of CKIP-1 Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Natural Science Foundation Council Project ID: NSFC 81272045 Exercise Year: 2012/2013 Approved Project Duration: 36 months Project Fund: RMB 700,000 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 4 | Title: Toward a novel bone anabolic strategy for aged postmenopausal osteoporosis: Inhibiting miR- 214 inosteogenic cells for promoting bone formation Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund Project ID: HKBU 478312 Exercise Year: 2012/2013 Approved Project Duration: 30 months Project Fund: HK$ 950,000 Coordinator: Dr. Baosheng Guo (Ph.D.) |
Project 5 | Title: Establishing the bridge for translating cell-specific RNA interference to bone anabolictherapy: An aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality Project ID: SCM-2013-SZTIC-001 Exercise Year: 2013/2014 Approved Project Duration: 24 months Project Fund: RMB 300,000 Coordinator: Dr. Chao Liang (PH.D.) |
Project 6 | Title: Research and development of triptolide-aptamer drug Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: National Science and Technology Major Projects for "major New Drugs Innovation and Development" Project ID: 2013ZX09301307 Exercise Year: 2013/2015 Approved Project Duration: 36 months Project Fund: RMB 1,500,000 Coordinator: Dr. Xiaojuan He (M.D.) |
Project 7 | Title: Understanding the molecular mechanism in failure of osteoblast-mediated repair for articular bone erosion during progressive rheumatoid arthritis:Role of casein kinase-2 interacting protein-1 in controlling osteoblast function Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: HKBU261113 Exercise Year: 2013/2014 Approved Project Duration: 30 months Project Fund: HK$ 606,223 Coordinator: Dr. Chao Liang (PH.D.)
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Project 8 | Title: Aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs to achieve cell-specific RNA interference for bone anabolic therapy Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: HKBU12102914 Exercise Year: 2014/2015 Approved Project Duration: 36 months Project Fund: HK$ 1,035,000 Coordinator: Dr. Chao Liang (Ph.D.) |
Project 9 | Title: Toward Targeted Therapy In Advanced Pancreatic Cancer: A Smart Triptolide-Nucleolin Aptamer Conjugate (UIM/256) Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Hong Kong Innovation and Technology Fund Project ID: UIM/256 Exercise Year: 2014/2016 Approved Project Duration: 24 months Project Fund: HK$ 2,339,560 Coordinator: Mr. Biao Liu (M.S.) |
Project 10 | Title:Toward Cell-targeted Therapeutics in Osteosarcoma: a Smart Triptolide-aptamer Conjugate Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) and Prof. Dean Guo (Ph.D.) Funding Body: Croucher Foundation Project ID: Gnt#CAS14BU/CAS14201 Exercise Year: 2014/2016 Approved Project Duration: 36 months Project Fund: HK$ 1,200,000 Coordinator: Dr. Defang Li (Ph.D.) and Dr. Chao Liang (Ph.D.) |
Project 11 | Title: Role of osteoclast-derived exosomal miR-214 in regulating osteoblastic bone formation Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: HKBU12114416 Exercise Year: 2016/2017 Approved Project Duration: 36 months Project Fund: HK$ 1,334,644 Coordinator: Dr.Jin Liu (Ph.D.) |
Project 12 | Title: Does aberrantly overexpressed CKIP-1 suppress osteoblast-mediated articular bone repair in inflammatory arthritis? A collagen-induced non-human primate arthritis model Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: HKBU12122516 Exercise Year: 2016/2017 Approved Project Duration: 30 months Project Fund: HK$ 795,400 Coordinator: Dr.Xiaojuan He (M.D.)
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Project 13 | Title: Molecular mechanisms of obesity with chinese medicine pattern of phlegm-dampness and its changes on hypertension Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) Funding Body: Natural Science Foundation Council Project ID: NSFC - General Program81673773 Exercise Year: 2016/2017 Approved Project Duration: 24 months Project Fund: RMB590,000 Coordinator: Dr.Xiaojuan He (M.D.) |
Project 14 | Title: The role of osteoclastic miR-214-3p during the development of osteolytic bone metastasis of breast cancer Principal Investigator: Prof. Li Defang (Ph.D.) Funding Body: Natural Science Foundation Council Project ID: NSFC - Young Scientists Fund8160111219 Exercise Year: 2016/2017 Approved Project Duration: 36 months Project Fund: RMB190,000 Coordinator: Dr.Jin Liu (Ph.D.) |
Project 15 | Title: Targeting Sclerostin to Reverse Established Osteoporosis: Aptamer Characterization and Evaluation for Drug Discover Principal Investigator: Dr.Yu Yuanyuan (Ph.D.) Funding Body: Natural Science Foundation Council Project ID: NSFC - Young Scientists Fund81601929 Exercise Year: 2016/2017 Approved Project Duration: 36 months Project Fund: RMB 180,000 Coordinator: Dr.Yu Yuanyuan (Ph.D.) |
Project 16 | Title: Targeting Sclerostin to Reverse Established Osteoporosis: Aptamer Characterization and Evaluation for Drug Discover Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Hong Kong Innovation and Technology Fund Project ID: UIM/298 Exercise Year: 2016/2017 Approved Project Duration: 24 months Project Fund: HK$ 1,000,000 Coordinator: Dr.Yu Yuanyuan (Ph.D.)
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Project 17 | Title: The role of osteoclastic miR-214-3p in early osteoarthritis development Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: HKBU12101117 Exercise Year: 2016/2017 Approved Project Duration: 36 months Project Fund: HK$ 871,855 Coordinator: Dr.Jin Liu (Ph.D.) |
Project 18 | Title: Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma Principal Investigator: Dr. Fangfei Li (Ph.D.) Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality Project ID: JCYJ20170307161659648 Exercise Year: 2017/2019 Approved Project Duration: 24 months Project Fund: RMB 300,000 Coordinator: Dr. Fangfei Li (Ph.D.) |
Project 19 | Title: An innovative immuno-chemotherapy for triple-negative breast cancer: PD-L1 aptamer-paclitaxel conjugate cancer Principal Investigator: Prof. Ge Zhang (M.D.) Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality Project ID: JCYJ20160229210357960 Exercise Year: 2016/2019 Approved Project Duration: 36 months Project Fund: RMB3,000,000 Coordinator: Dr. Fangfei Li (Ph.D.)
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Project 20 | Title: Research on Efficacy and Mechanism of Pien Tze Huang in Multiple Sclerosis for New Drug Discovery Principal Investigator: Dr. Xiaojuan He (Ph.D.) Funding Body: Hong Kong Innovation and Technology Fund Project ID: UIM/310 Exercise Year: 2017/2018 Approved Project Duration: 18 months Project Fund: HK$ 1,428,300 Coordinator: Dr. Xiaojuan He (Ph.D.)
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Project 21 | Title: Molecular Mechanism for Bone Formation Reduction During Aging: Functional Role of Plekho1 in Regulating BMP Signaling Principal Investigator: Dr. Baosheng Guo(Ph.D.) Funding Body: The Young Scholars Program of National Natural Science Foundation of China Project ID: NSFC 81401833 Exercise Year: 2015/2017 Approved Project Duration: 36months Project Fund: RMB: 230,000 Coordinator: Dr. Baosheng Guo(Ph.D.) |
Project 22 | Title: Understanding the mechanical loading-independent communication from skeletal muscle to bone: the role of muscle-derived exosomal miR-206 in regulating bone formation during muscle atrophy Principal Investigator: Dr. Baosheng Guo(Ph.D.) Funding Body: Hong Kong General Research Fund (GRF) Project ID: NSFC 81401833 Exercise Year: 2017/2018 Approved Project Duration: 24months Project Fund: HK$ 653,436 Coordinator: Dr. Baosheng Guo(Ph.D.) |
Project 23 | Title: A delivery system specifically targeting osteoclasts for encapsulating osteoclastic miRNAs modulator to inhibit bone resorption Principal Investigator: Dr. Baosheng Guo(Ph.D.) Funding Body: The General Program of National Natural Science Foundation of China (NSFC) Project ID: NSFC 81572195 Exercise Year : 2016/2019 Approved Project Duration: 36months Project Fund: RMB: 600,000 Coordinator: Dr. Baosheng Guo(Ph.D.) |
Project 24 | Title: Functional Role of Plekho1 for regulating BMP Signaling during bone formation reduction in aged osteoporosis Principal Investigator: Dr. Baosheng Guo(Ph.D.) Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality (STICSM) Project ID: JCYJ20140905100736938 Exercise Year : 2015/2017 Approved Project Duration: 24months Project Fund: RMB: 300,000 Coordinator: Dr. Baosheng Guo(Ph.D.) |
