Note: TMBJ academic staffs’ name are highlighted with blue.


Published Conference Abstract in 2019


1.         

Liu J, Dang L, Wu X, Lu J, Zhang H, Zhong C, Lu A, Zhang G. Unraveling the mystery behind bone-cartilage crosstalk: Osteoclast derived exosomal microRNAs deprive the resistance of cartilage to matrix degeneration, angiogenesis and innervation in osteoarthritis. ASBMR 2019, 19th -23rd September 2019, Orlando, USA.

2.         

Ren Q, Xie D, Yu Y, Tang Y, Ni S, Lu J, Lu A, Zhang GA potential next-generation sclerostin inhibitor specifically targets    sclerostin monomer for bone anabolic therapy with low cardiovascular risk in osteogenesis imperfecta mice. ASBMR 2019,  19th -23rd September 2019, Orlando, USA.

3.         

Li F, Wu X, Fu X, Lu A, Zhang G. PARP1 interacts with ezrin contributing to metastasis in osteosarcoma. ASBMR 2019, 19th -23rd September 2019, Orlando, USA.

4.         

Yu Y, Ren Q, Ni S, Liu J, Zhong C, Lu J, Tang Y, Li D, Xie D, Dai R, Zhuang H, Dang L, Lu A, Zhang GA Potential Next Generation Sclerostin Inhibitor Specifically Targets Sclerostin Monomer for Bone Anabolic Therapy with Low Cardiovascular Risk to Reverse Established Osteoporosis in Ovariectomized Rats. ASBMR 2019, 19th -23rd September 2019, Orlando, USA.

5.         

 Li D, Yang C, Chen Z, Zhao F, Qian A, Liu J, Liang C, Guan D, Ni S, Ren Q, Tang Y, Wu X, Lu A, Zhang G. Targeting a newly identified lncRNA and its interaction with HuR to promote osteogenic cells migration to bone formation surface for reversing established age-related osteoporosis. ASBMR 2019, 19th -23rd September 2019, Orlando, USA.



Published Conference Abstract in 2017

 

1.         

Yu Y, Li Y, Wu X, Li F, Lu A, Zhang G. An innovative gain-loss cell-SELEX strategy for development of a nucleic acid aptamer against PD-L1 for immunotherapy of triple negative breast cancer. Aptamer 2017, 11-12 April 2017. Oxford, UK.

2.         

Liang C, Peng S, Zhang BT, Lu Aiping, Zhang G. From precision medicine to drug discovery: inhibition of osteoblastic Smurf1 promotes bone formation in distinctive individuals with age-related osteoporosis. 2017 ICMRS-ORS Membership Meeting, March 20, 2017. San Diego, California, USA.

3.         

Liang C, Peng S, Zhang BT, Lu Aiping, Zhang G. From precision medicine to drug discovery: inhibition of osteoblastic Smurf1 promotes bone formation in distinctive individuals with age-related osteoporosis. 2017 ORS Annual Meeting, March 19-22, 2017. San Diego, California, USA.

4.         

Liu J, Wu X, Lu A, Zhang G. Elevated osteoclastic miR-214-3p targets TIMP2 to promote subchondral bone remodeling in early osteoarthritis. OARSI 2017 World Congress on Osteoarthritis, April 27 ­ 30, 2017. Las Vegas, Nevada, USA.

 

 

Published Conference Abstract in 2016

 

1.         

Yu Y, Liang C, Lv Q, Li D, Xu X, Liu   B, Lu A, Zhang G. Molecular Selection, Modification and Development of TherapeuticOligonucleotide Aptamers. Aptamers 2016, Oxford, April 4-5, 2016.

2.         

Wu X.H., Liu J, Xiao L.B., Lu A.P., Zhang G. Alterations of gut microbiome in rheumatoid arthritis. Oral Abstract. Webster Jee Travel Award, the 8th International Conference on Osteoporosis and Bone Research,19-22 October, 2016, Chong Qing, China.

3.         

Wang L.Y.,   Liang C, Li F.F., Zhang G, Lu A.P. Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGF-A in osteosarcoma. Oral Abstract. Webster Jee Travel Award, the 8th International Conference on Osteoporosis and Bone Research, 19-22 October, 2016, Chong Qing, China.

4.         

Liang C, Peng S, Zhang BT, Lu Aiping, Zhang G. Inhibition of osteoblastic Smurf1 promotes bone formation in distinctive individuals with age-related osteoporosis. Oral Abstract. 8th International Conference on Osteoporosis and Bone Research, October 19-22, 2016, Chongqing, China.

 

 

 

Published Conference Abstract in 2015

 

5.         

Guo B, Lu A, Zhang B, Zhang G. Therapeutic inhibition of miR-214 by (AspSerSer)6-liposome encapsulating antagomir-214 in osteoblast cells for promoting bone formation in aged osteoporotic rats. 2015 Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

6.         

Liang C, Guo B, Wu H, Zhang L, Lu A, Zhang G. Aptamer-functionalized delivery system for osteogenic siRNAs to achieve osteoblast-specific RNA interference for bone anabolic therapy. 2015 Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

7.         

Lv C, Liu J, Guo B, Li D, Liang C, Zhang B, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 expression and decreased phosphorylated Smad1/5 within osteoblasts during bone formation   reduction in glucocorticoid-induced osteoporotic rats. 2015 Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

8.         

Li D, Liu J, Guo B, Liang C, Dang L, He X, Liang Z, Lu A, Zhang G. Exosome-encapsulated miR-214 secreted from osteoclast to inhibit osteoblastic activity. 2015 Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

9.         

Liu J, Guo B, Li D, Liang C, Dang L, He X, Zhang B, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 within osteoblast suppress BMP signaling to inhibit bone formation during aging. 2015 Orthopaedic Research Society (ORS) annual   meeting, Las Vegas, March 28-31, 2015.

10.      

Dang L, Guo B, Li D, Liu J, Liang C, He X, Wu H, Yang Z, Liang Z, Lu A, Zhang G. Adelivery system approach bone resorption surface for specifically targeting osteoclasts in vivo. 2015 Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015. 

11.      

Li D, Liu J, Guo B, Dang L, Liang C, He X, Lu A, Zhang G. Elevated miR-214 level within osteoclasts associates with increased bone resorption in both postmenopausal osteoporosis and osteolytic bone metastasis. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

12.      

Li D, Liu J, Guo B, Liang C, Dang L, Lu A, Zhang G. Osteoclast-derived exosomal miR-214 inhibits osteoblastic bone formation. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

13.      

Liu J, Li D, Guo B, Dang L, Lu A, Zhang G. Osteoclastic miR-214 targets PTEN to increase bone resorption. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

14.      

Liu J, Lv C, Guo B, Li D, Liang C, Pan X, Zhang L, Zhang B, Lu A, Zhang G. Highly expressed CKIP-1 inhibits BMP signaling pathway to suppress osteogenic differentiation and mineral deposition in osteoblast during glucocorticoid treatment in vitro. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

15.      

Liu J, Zhang Z, Li J, Guo B, Zhang B, Lu A, Zhang G. Targeting CKIP-1 within osteoblast: A potential anabolic strategy for bone formation reduction during aging? American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

16.      

Dang L, Zhang G, Li D, Liu J, Guo B, Lu A. Targeted inhibition of miR-214 in osteoclasts suppresses bone resorption in both ovariectomy-induced osteoporosis and osteolytic bone metastasis in vivo. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

17.      

Liang C, Xu M, Zhou X, Wang K, Xu J, Zhang B, Lu A, Zhang G. Discovery of Small Molecules to Promote BMP Signaling and Bone Formation. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

18.      

Qian A, Chen Z, Arfat Y, Hu L, Shang P, Zhang G. Mechanical unloading sensitive miR-138 targets MACF1 to regulate bone formation. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015

19.      

Hu L, Su P, Li R, Yin C, Yan K, Zhang G, Shang P, Qian A. A Novel Role of MACF1: Positively Regulates Osteoblast Differentiation. American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015

20.      

Wei Zhou, Defang Li, Jin Liu, Lu A, Zhang G.Toward blockade of cartilage breakdown in rheumatoid arthritis: Prediction of therapeutic targets from lncRNA Hotair–mediated network modeling. RNAi China, September 12, 2015

21.      

Defang Li, Jin Liu, Lu A, Zhang G.Osteoclast-derived exosomal miR-214 inhibits osteoblastic bone formation. RNAi China, September 12, 2015

22.      

Fangfei Li, Bing He, Chao Wang, Lu A, Zhang G.Transcriptional inhibition of miR214 for treating osteosarcoma: controllable CRISPR/Cas9 drug and aptamer-based targeted delivery. RNAi China, September 12, 2015

23.      

Feng Jiang, Lu A, Zhang G.Progress and challenges in developing aptamer-functionalized targeted drug delivery systems. RNAi China, September 12, 2015

24.      

Xiaojuan He, Lu A, Zhang G.Inhibition of CKIP-1 within osteoblast promoted bone formation-mediated reparative process in mice with collagen-induced arthritis. RNAi China, September 12, 2015

 

 

Published Conference Abstract in 2014

 

25.      

Junzhe Huang, Jun Lu, Biao Liu, Xiaojuan He, Ge Zhang, Aiping Lu. Fibroblast like synoviocytes (FLS)-specific aptamer facilitates the conjugated-triptolide selectively targeting rheumatic joints with less exposure to liver in rodents. 8th European Workshop on Immune-Mediated Inflammatory Diseases. Funchal - Madeira, Portugal. November 5-7, 2014.

26.      

Xiaojuan He, Kang Zheng, Yukun Zhao, Baosheng Guo, Jin Liu, Ge Zhang, Aiping Lu. Aberrant overexpression of CKIP-1 in osteoblast correlated with progressive bone erosion and decreased bone formation in collagen-induced arthritis of mice. 7th International Conference on Osteoporosis and Bone Research, 2014. Xiamen, China. October 16-19, 2014 (Accepted).

27.      

Baosheng Guo, Aiping Lu, Baoting Zhang, Ge Zhang. Inhibition of miR-214 by (Asp-Ser-Ser)6-liposome capsulated antagomiR-214 in osteogenic cells of aged osteoporotic rats: Quantification analysis for expression levels of miR-214, osteocalcin mRNA and ATF4 protein in osteogenic cells. 2014 American Orthopaedics Society Annual Meeting, New Orleans, Louisiana March 15-18 (http://www.ors.org/Transactions/60/0604.pdf).

28.      

Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous Plekho1 for promoting bone formation in a rat model of aged postmenopausal osteoporosis (http://www.ors.org/Transactions/60/0566.pdf). 2014 American Orthopaedics Society Annual Meeting, New Orleans, Louisiana March 15-18.

29.      

Baosheng Guo, Jin Liu, Heng Wu, Lingqiang Zhang, Ling Qin, Aiping Lu, Baoting Zhang, Ge Zhang. Ckip-1 in osteoblasts plays an inhibition role in bone formation in aged male osteoporosis. MOLECULAR THERAPY. Vol. 22. Suppl.1 S39-S40. American Society of Gene & Cell Therapy 17th Annual Meeting. Washingon, DC. May 21-24, 2014.

30.      

Baosheng Guo, Liu Jin, Dang lei, Liang Chao, Xiaohua Pan, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Up-regulated CKIP-1 expression within osteoblasts associates with reduced BMP signaling and decreased bone formation during aging. 5th Sino-American   Symposium on Clinical and Translational Medicine (SAS-CTM). Beijing, China. June 21-22, 2014.

31.      

Baosheng Guo, Liu Jin, Heng Wu, Dang lei, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous Ckip-1 for promoting bone formation in an aged rat model of male osteoporosis. ASBMR 2014 Annual  Meeting. Houston, Texas. September 12-15, 2014.

32.      

Baosheng Guo, Liang Chao, Xiaohua Pan, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Up-regulated CKIP-1 expression within osteoblasts associates with reduced BMP signaling and decreased bone formation during aging. 7th International Conference on Osteoporosis and Bone Research, 2014. Xiamen, China. October 16-19, 2014 (Accepted).

33.      

Defang Li, Chao Liang, Baosheng Guo, Jin Liu, Lei Dang, Liang Xu, Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang. DNM3 Participates in Exosome-Mediated miR-214 Transfer From Differentiating Osteoclasts To Regulate Osteoblastic Activity: In Vitro Evidences. MOLECULAR THERAPY. Vol. 22. Suppl.1 S158-S158. American Society of Gene & Cell Therapy 17th Annual Meeting. Washingon, DC. May 21-24, 2014.

34.      

Defang Li, Chao Liang, Baosheng Guo, Jin Liu, Lei Dang, Liang Xu, Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang. Exosome-encapsulated miR-214 secreted from osteoclast to inhibit osteoblastic activity. ASBMR 2014 Annual Meeting. Houston, Texas. September 12-15, 2014 (Accepted).

35.      

Biao Liu, Xiaojuan He, Ge Zhang, Aiping Lu. A novel triptolide-nucleolin aptamer conjugate (TMPC001) with super antitumor activity on advanced pancreatic cancer. Planta Med 2014; 80 - CL26 DOI: 10.1055/s-0034-1382359.

36.      

Biao Liu, Baosheng Guo, Xiaojuan He, Defang Li , Ge Zhang, Aiping Lu. A novel Triptolide-Nucleolin aptamer conjugate with super antitumor activity on advanced pancreatic cancer cell in vitro. MOLECULAR THERAPY. Vol. 22. Suppl.1 S221-S221. American Society of Gene & Cell Therapy 17th Annual Meeting. May 21-24, 2014.

37.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge  Zhang. Aptamer-Functionalized Lipid Nanoparticles (LNPs) Targeting Osteoblasts as a Novel RNA Interference-Based   Bone Anabolic Strategy. ASBMR 2014 Annual Meeting. Houston, Texas. September 12-15, 2014 (Accepted).

38.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge   Zhang. Aptamer-Functionalized Lipid Nanoparticles (LNPs) Targeting Osteoblasts as a Novel RNAi-Based Bone   Anabolic Strategy. 5th Sino-American Symposium on Clinical and Translational Medicine (SAS-CTM). Beijing, China. June 21-22, 2014.

39.      

Chao Liang, Baosheng Guo, Heng Wu, Lei Dang, Zhijun Yang, Lingqiang Zhang, Aiping Lu, Ge Zhang. Development of aptamer-functionalized osteoblast-targeting lipid nanoparticles encapsulating osteogenic siRNAs for bone anabolic therapy: investigation of tissue-selective distribution, dose-response pattern and persistence of gene silencing. Orthopaedic Research Society (ORS) 2014 annual meeting. March 15-18, 2014 (http://www.ors.org/Transactions/60/1160.pdf).

40.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge  Zhang. Aptamer-functionalized lipid nanoparticles (LNPs) targeting osteoblasts as a novel RNA interference (RNAi)-based bone anabolic strategy. The 7th   International Conference on Osteoporosis and Bone Research (ICOBR 2014). October 16-19, 2014 (Accepted).

41.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge  Zhang. Aptamer-functionalized delivery system for osteogenic siRNAs to achieve osteoblast-specific RNA interference for bone anabolic therapy. Orthopaedic Research Society (ORS) 2015 annual meeting. Xiamen, China. March 28-31, 2015 (Submitted).

42.      

Lei Dang, Baosheng Guo, Defang Li, Aiping Lv, Ge Zhang. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of miRNAs in osteoclasts. MOLECULAR THERAPY. Vol. 22. Suppl.1. S131-S131. American Society of Gene & Cell Therapy (ASGCT) 2014 annual meeting, Washington, USA. May 21-24, 2014.

43.      

Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang, Zicai Liang, Aiping lu, Ge Zhang. A peptide-modified delivery system specifically approaching bone resorption surfaces for therapeutic modulation of miRNAs in osteoclasts. American Society for Bone and Mineral Research (ASMBR) 2014 annual meeting, Houston, USA, September 12-15, 2014.

44.      

Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang, Zicai Liang, Aiping lu, Ge Zhang. A delivery system to approache bone resorption surfaces for specifically targeting osteoclasts in vivo. Orthopaedic Research Society (ORS) 2015 annual meeting, Las Vegas, USA, March 24-28, 2015 (Submitted).

45.      

Jun Lu, Biao Liu, Xiaojuan He, Jie Xu, Aiping Lu, Ge Zhang.A novel method for aptamer-triptolide conjugate linked by an acid-labile vinyl ether bond: synthesis, characterization and pH-sensitive biological properties of the conjugate.University Town campus of NUS, Singapore. December 14-17, 2014.

 

 

 

Published Conference Abstract in 2013

 

1.        

Baosheng Guo, Baoting Zhang, Jun Wang, Chao Liang, Heng Wu, Zhijun Yang, Albert H. L. Chow, Zhibo Hou, Yadong Huang, Fuchu He, Ling   Qin, Lingqiang Zhang, Zhaoxiang Bian, Aiping Lu, Ge Zhang. (Asp-Ser-Ser)6 facilitates bone anabolic siRNA specifically targeting osteogenic cells in aged ovariectomized rats. 2013 Orthopaedics Research Society Annual Meeting. San Antonio, Texas. January 26–29, 2013 (http://www.ors.org/Transactions/59/PS2--082/1465.html).

2.        

Baosheng Guo, Xiaogang Wang, An Hong, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic inhibition of miR-214 within osteogenic cells in aged osteoporotic rats induced by ovariectomy for bone anabolic strategy: Optimization of dosage and duration. Bone Joint J 2014 vol. 96-B no. SUPP 11. 8th Combined Meeting of Orthopaedic Research Societies. San Servolo Venice, Italy. October 13-16, 2013.

3.        

Baosheng Guo, Xiaogang Wang, An Hong, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous PLEKHO1   for promoting bone formation in a rat model of aged postmenopausal osteoporosis. RNAi China, 2013. Kunshan, China. June 20-22, 2013.

4.        

Bing He, Jin Liu, Tao Tang, Baosheng Guo, Xiaohua Pan, Aiping Lu and Ge Zhang. Potential strategy regulating miRNAs to improve impaired fracture healing in aged females: A systematic view for timing and targets. Bone Joint J. 2014 vol. 96-B no. SUPP 11 207. 8h Combined Meeting of Orthopaedic Research Societies. San Servolo Venice, Italy. October 13-16, 2013.

5.        

Jin Liu, Baosheng Guo, Yixin He, Xiaohua Pan, Lei Dang, Lingqiang Zhang, Aiping Lu, Ge Zhang. Could casein kinase-2 interacting protein-1 (CKIP-1) be postulated as a molecular target for promoting aged fracture repair in females? JOURNAL OF BONE AND MINERAL RESEARCH. Vol. 28. Suppl. 1. 2013 American Society of Bone and Mineral Research Annual Meeting. Baltimore, Maryland, USA. October 4–7, 2013.

 

 

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