Administration Committee,Institute for Advancing Translational Medicine in Bone & Joint Diseases Hong Kong Baptist University

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◆ Associate Professor
◆ Executive Director of Institute for Advancing Translational Medicine in Bone & Joint Diseases
◆ Major: Clinical Orthopedics & Musculoskeletal Science
◆ E-mail: zhangge@hkbu.edu.hk

Name: Zhang Ge

Academic qualifications:
1990.9-1995.7	B. Med	Shanghai University of Chinese Medicine, Shanghai, China
1997.9-2000.7	M. Med.	Institute of Orthopaedics & Traumatology, Shanghai University of Chinese Medicine, China
2000.9-2003.7	M.D.	Institute of Orthopaedics & Traumatology, Shanghai University of Chinese Medicine & Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong

Previous academic positions held:
1995.8-2000.11	Resident	Institute of Orthopaedics & Traumatology, Shu Guang Hospital, Shanghai University of Chinese Medicine
2000.12-2004.2	Physician-in-Charge	Institute of Orthopaedics & Traumatology, Shu Guang Hospital, Shanghai University of Chinese Medicine
2004.3-2007.6	Postdoctoral Research Fellow	Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong
2007.7-2012.8	Research Assistant Professor	Department of Orthopaedics & Traumatology, The Chinese University of Hong Kong

Present academic position:
2012.9-	Associate Professor	Ge Zhang’s Lab (www.gezhanglab.com), Institute for Advancing Translational Medicine in Bone & Joint Diseases, Hong Kong Baptist University & Teaching Division, School of Chinese Medicine, Hong Kong Baptist University

Previous relevant research work:

Technical expertise

Bone bio-imaging, Bone histomorphometry, Bone biology, Bone biomechanics

Research area

Molecular understandings and RNAi-based & phytotherapy-based translational research in osteoporosis, osteonecrosis, osteoarthritis, rheumatoid arthritis and facture repair

Publication Records: 3 Theses; 9 Book Chapters; 106 SCI Papers; Sum of the Times cited (excluding self-citation): 220; h-index: 9

Ten Representative publications in the past ten years

1.	Wang X, Guo B, …, Zhang G (Corresponding Author), Li Y (Corresponding Author). miR-214 targets ATF4 to inhibit bone formation. *Nat Med.* 2013 Jan;19(1):93-100
2.	Zhang G (Corresponding Author), Guo B, Wu H, Tang T, Zhang BT, …, Zhang L (Corresponding Author), Qin L (Corresponding Author). A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. *Nat Med.* 2012 Jan 29;18(2):307-14
3.	He YX, Liu Z, Pan XH, Tang T, Guo BS, Zheng LZ, Xie XH, Wang XL, Lee KM, Li G, Cao YP, Wei L, Chen Y, Yang ZJ, Hung LK, Qin L, Zhang G (Corresponding Author).Deletion of estrogen receptor beta accelerates early stage of bone healing in a mouse osteotomy model. *Osteoporosis Int.* 2012 Jan;23(1):377-89.
4.	Zhang G, Sheng H, et al. Continuous occurrence of both insufficient neovascularization and elevated vascular permeability in rabbit proximal femur during inadequate repair of steroid-associated osteonecrotic lesions. *Arthritis Rheum.* 2009 Oct;60(10):2966-77.
5.	Zhang G, Wang XL, Sheng H, et al. Constitutional flavonoids derived from Epimedium dose-dependently reduce incidence of steroid-associated osteonecrosis not via direct action by themselves on potential cellular targets. *PlosOne* 2009; 4: e6419.
6.	Zhang G, Qin L, et al. A Novel Semisynthesized Small Molecule Icaritin Reduces Incidence of Steroid-associated Osteonecrosis with Inhibition of both Thrombosis and Lipid-deposition in a Dose-dependent Manner. *Bone*2009; 44: 345-56.
7.	Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. *J Bone Miner Res.* 2007 Jul;22(7):1072-9.
8.	Zhang G, Qin L, et al. Flavonoids derived from herbal Epimedium Brevicornum Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement in intestinal calcium absorption. *Bone.* 2006 Jun;38(6):818-25.
9.	Zhang G (Corresponding Author), et al. A comparative study between axial compression and lateral fall configuration tested in a rat proximal femur model. *Clin Biomech (Bristol, Avon).* 2005 Aug;20(7):729-35.