The first multicenter and randomized clinical trial of   herbal Fufang for treatment of postmenopausal osteoporosis.Osteoporos Int.   2012 Apr;23(4):1317-27.The first multicenter and randomized clinical trial of   herbal Fufang for treatment of postmenopausal osteoporosis.Osteoporos Int.   2012 Apr;23(4):1317-27.Note: TMBJ academic staffs’ name are highlighted with blue.



Impact Factor>=9 (Journal Citation Report 2014)




Zong-Kang Zhang (Co-first Author), Jie Li (Co-first author), Daogang Guan (Co-first author), Chao Liang (Co-first author), Zhenjian Zhuo, Jin Liu, Aiping Lu (Corresponding author), Ge Zhang (Corresponding author), Bao-Ting Zhang (Corresponding author). A newly identified lncRNA MAR1 acts as a miR-487b sponge to promote skeletal muscle differentiation and regeneration. J Cachexia Sarcopenia Muscle. (Accepted).


Fangfei Li (first Author), Jun Lu (Co-first Author), Jin Liu (Co-first Author), Chao Liang (Co-first Author), Maolin Wang (Co-first Author), Luyao Wang (Co-first Author), Defang Li, Houzong Yao, Qiulong Zhang, Jia Wen, Zong-Kang Zhang, Jie Li, Quanxia Lv, Xiaojuan He, Baosheng Guo, Daogang Guan, Yuanyuan Yu, Lei DangCo-, Xiaohao Wu, Yongshu Li, Guofen Chen, Feng Jiang, Shiguo Sun, Bao-Ting Zhang (Corresponding author), Aiping Lu (Corresponding author), Ge Zhang (Corresponding author), A water-soluble nucleolin aptamer-paclitaxel conjugate for tumor-specific targeting in ovarian cancer. Nat Commun.2017 Nov 9. DOI: 10.1038/s41467-017-01565-6.



Li D (Co-first Author), Liu J (Co-first Author), Guo B, Liang C, Dang L, Lu C, He X,   Cheung HY, Xu L, Lu C, He B, Liu B, Shaikh AB, Li F, Wang L, Yang Z, Au DW,   Peng S, Zhang Z, Zhang BT, Pan X, Qian A, Shang P, Xiao L, Jiang B, Wong CK,  Xu J, Bian Z, Liang Z, Guo DA, Zhu H, Tan W, Lu A (Corresponding author), Zhang G   (Corresponding author). Osteoclast-derived exosomal miR-214-3p inhibits   osteoblastic bone formation. Nat Commun. 2016 Mar 7,   7:10872. doi: 10.1038/ncomms10872.



Liang C (Co-first Author), Guo B (Co-first Author), Wu H (Co-first Author), Shao N, Li D, Liu J, Dang L, Wang C,   Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C,   Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F,   Zhang L (Corresponding Author),  Lu A (Corresponding Author), Zhang G   (Corresponding Author). Aptamer-functionalized lipid nanoparticles targeting   osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat   Med. 2015 Feb 9. doi: 10.1038/nm.3791.



Wang X (Co-first Author), Guo B (Co-first Author), Li Q, Peng J, Yang Z, Wang A, Li D,   Hou Z, Lv K, Kan G, Cao H, Wu H, Song J , Pan X, Sun Q, Ling S, Li Y, Zhu M,   Zhang P, Peng S, Xie X, Tang T, Hong A, Bian Z, Bai Y, Lu A, Li Y, He FZhang G (Corresponding Author), Li Y(Corresponding Author). miR-214 targets   ATF4 to inhibit bone formation. Nat Med. 2013 Jan;19(1):93-100.


Zhang G   (Corresponding Author), Guo B (Co-first Author), Wu H (Co-first Author), Tang T (Co-first Author), Zhang BT (Co-first Author), Zheng L, He Y, Yang Z, Pan X, Chow   H, To K, Li Y, Li D,Wang X, Wang Y, Lee K, Hou Z, Dong N, Li G, Leung K, Hung   L, He F, Zhang L (Corresponding Author), Qin L (Corresponding Author). A   delivery system targeting bone formation surfaces to facilitate RNAi-based   anabolic therapy. Nat Med. 2012 Jan 29;18(2):307-14.



 5=<Impact Factor<9 (Journal Citation Report 2014)




Liang C (Co-first author), Li F (Co-first author), Wang L (Co-first author), Zhang ZK (Co-first author), Wang C (Co-first author), He B, Li J, Chen Z, Shaikh AB, Liu J, Wu X, Peng S, Dang L, Guo B, He X, Au DWT, Lu C, Zhu H (Corresponding author), Zhang BT (Corresponding author),Lu A (Corresponding author) , Zhang G (Corresponding author).Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for therapeutic genome editing of VEGFA in osteosarcoma. Biomaterials2017; 147: 68-85.


Liu J, Li D, Wu X, Dang L, Lu A, Zhang G(Corresponding Author).Bone-derived exosomes.Current Opinion in Pharmacology. 2017; 34:64-69.


Zhu S, Yao F, Qiu H, Zhang G, Xu H, Xu J.Coupling factors and exosomal packaging microRNAs involved in the regulation of bone remodeling. Biological Reviews. 2017. Doi:10.1111/brv.12353.



Hu L, Xiao Y, Xiong Z, Zhao F, Yin C, Zhang Y, Su P, Li D, Chen Z, Ma X, Zhang G, Qian A.MACF1, versatility in tissue-specific function and in human disease. Seminars in Cell & Developmental Biology. 2017 May 31.



Zong-Kang Zhang (Co-first Author), Jie Li (Co-first Author), Jin Liu,   Baosheng Guo, Albert Leung (Corresponding Author), Zhang G(Corresponding Author) ,Bao-Ting Zhang (Corresponding Author). Icaritin requires   Phosphatidylinositol 3 kinase (PI3K)/Akt signaling to counteract skeletal   muscle atrophy following mechanical unloading. SCIENTIFIC REPORTS. 6:20300 DOI:   10.1038/srep20300(2016).



Zheng LZ, Cao   HJ, Chen SH, Tang T, Fu WM, Huang L, Chow DH, Wang YX, Griffith JF, He W,   Zhou H, Zhao W,Zhang G(Corresponding Author), Wang XL, Qin L. Blockage of Src by Specific siRNA as a   Novel Therapeutic Strategy to Prevent Destructive Repair in   Steroid-Associated Osteonecrosis in Rabbits. J Bone Miner Res. 2015 Apr 27. doi: 10.1002/jbmr.2542.


Jin Liu (Co-first   Author), Lei Dang (Co-first Author), Defang Li (Co-first   Author),Chao Liang, Xiaojuan He, Heng Wu, Airong Qian, Zhijun Yang, Doris   W.T. Au, Michael W.L. Chiang h, Bao-Ting Zhang, Quanbin Han, Kevin K.M. Yue,   Hongqi Zhang, Changwei Lv, Xiaohua Pan, Jiake Xu, Zhaoxiang Bian, Peng Shang,   Weihong Tan, Zicai Liang, Baosheng Guo, Aiping Lu (Corresponding Author), Zhang G(Corresponding Author).A delivery system specifically approaching bone   resorption surfaces to facilitate therapeutic modulation of microRNAs in   osteoclasts. Biomaterials. 52 (2015) 148-160.



Yi-Xin He (Co-first   Author), Jin Liu (Co-first Author), Baosheng Guo (Co-first Author),   Yi-Xiang Wang, Xiaohua Pan, Defang Li, Tao Tang, Yang Chen, Songlin Peng,   Zhaoxiang Bian, Zicai Liang, Bao-Ting Zhang, Aiping Lu (Corresponding Author), Zhang G(Corresponding Author). Src inhibitor reduces permeability   without disturbing vascularization and prevents bone destruction in   steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS. 5 : 8856 DOI: 10.1038/srep08856.



Wang S, Wei X,   Zhou J, Zhang J, Li K, Chen Q, Terek R, Fleming BC, Goldring MB,Ehrlich MG,Zhang G,Wei L. Identification of Alpha 2   Macroglobulin (A2M) as a master inhibitor of cartilage degrading factors that   attenuates post-traumatic osteoarthritis progressionArthritis   Rheumatol2014 Feb 27.


Zhang Z, Lu C   (Co-first author), Liu X, Su J, Dai W, Yan S, Lu A, Zhang W. Global and Targeted   Metabolomics Reveal that Bupleurotoxin, a Toxic Type of Polyacetylene,   Induces Cerebral Lesion by Inhibiting GABA receptor in Mice. J   Proteome Res. 2013 Dec 16.



Shek Man Chim,   Jennifer Tickner, Siu To Chow, Vincent Kuek, Baosheng Guo, Ge Zhang, Vicki Rosen, Wendy Erber, Jiake   Xu. Angiogenic factors in bone local environment. Cytokin Growth   Factor Rev. 2013 Apr 20. doi:pii:   S1359-6101(13)00028-2.10.1016/j.cytogfr. 2013.03.008. [Epub ahead of print].


Huang C, Zheng   C, Li Y, Wang Y, Lu A, Yang L. Systems pharmacology in drug discovery and   therapeutic insight for herbal medicines. Brief Bioinform. 2013   Jun 3. [Epub ahead of print].


Chen SH, Wang   XL, Xie XH, Zheng LZ, Yao D, Wang DP, Leng Y, Zhang G(Corresponding Author),Qin L (Corresponding Author).   Comparative study of osteogenic potential of a composite scaffold   incorporating either endogenous bone morphogenetic protein-2 or exogenous   phytomolecule icaritin: an in vitro efficacy study. Acta Biomater.   2012 Aug;8(8):3128-37.


Xie XH, Wang   XL, He YX, Liu Z, Sheng H,Zhang G(Corresponding Author), Qin L (Corresponding Author).   Promotion of bone repair by implantation of cryopreserved bone marrow-derived   mononuclear cells in a rabbit model of steroid-associated osteonecrosis. Arthritis   Rheum. 2012 May; 64(5):1562-71.


Tan Y, Li J,   Liu X, Ko J, He X, Lu C, Liu Z, Zhao H, Xiao C, Niu X, Zha Q, Yu Z, Zhang W, Lu A(Corresponding Author).Deciphering the differential toxic   responses of Radix aconiti lateralis praeparata in healthy and   hydrocortisone-pretreated rats based on serum metabolic profiles. J   Proteome Res. 2013 Jan 4; 2(1):513-24.



Zhang C, Jiang   M, Lu A (Corresponding Author). Considerations of traditional Chinese medicine as   adjunct therapy in the management of ulcerative colitis. Clin Rev   Allergy Immunol. 2013 Jun;44(3):274-83.


Zhao L,   Nicholson JK, Lu A, Wang Z, Tang H, Holmes E, Shen J, Zhang X, Li JV,   Lindon JC. Targeting the human genome-microbiome axis for drug discovery:   inspirations from global systems biology and traditional Chinese medicine. J   Proteome Res. 2012 Jul 6;11(7):3509-19.


Zhang G, Sheng H, He YX, Xie XH, Wang YX, Lee   KM, Yeung KW, Li ZR, He W, Griffith JF, Leung KS, Qin L. Continuous   occurrence of both insufficient neovascularization and elevated vascular   permeability in rabbit proximal femur during inadequate repair of   steroid-associated osteonecrotic lesions. Arthritis Rheum. 2009   Oct; 60(10):2966-77.



Zhang G, Qin L, Shi Y. Epimedium-derived phytoestrogen   flavonoids exert beneficial effect on preventing bone loss in late   postmenopausal women: a 24-month randomized, double-blind and   placebo-controlled trial. J Bone Miner Res. 2007   Jul;22(7):1072-9.



 Impact Factor<5 (Journal Citation Report 2014)





Xiaoqiu Wu (Co-first author), Atik Badshah Shaikh (Co-first tic Aauthor),Yuanyuan Yu (Co-first author),Yongshu Li (Co-first author),Shuaijian Ni (Co-first author),Lu A (Corresponding author), and Ge Zhang  (Corresponding author). Potential Diagnostic and Therapeupplications of oligonucleotide Aptamers in Breast Cancer.   Int. J. Mol. Sci. 2017.


Ni S, Yao H, Wang L, Lu J, Jiang F, Lu A (Corresponding author), and Ge Zhang  (Corresponding author).Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes.  Int. J. Mol. Sci. 2017.


Chen Z, Zhang Y, Liang C, Chen L, Ge Zhang   (Corresponding author). Mechanosensitive miRNAs and Bone Formation    Int. J. Mol. Sci. 2017.


Qiulong Zhang,   Huanhuan Lv, Feng Jiang, Aiping Lu (Corresponding author), and Ge Zhang   (Corresponding author).Recent Methods for Purification and Structure   Determination of Oligonucleotides.   Int. J. Mol. Sci. 2016, 17, 2134; doi:10.3390/ijms17122134.


Lv Q (Co-first   author), Meng Z (Co-first author), Yu Y (Co-first author), Jiang F, Guan D,   Liang C, Zhou J, .LuA (Corresponding author) and Zhang G (Corresponding   author). A Mini-review for Molecular Mechanisms and Translational Therapies of   HER2 Positive Breast Cancer[J].  Int. J. Mol. Sci,   2016.


Man Chen,   Yuanyuan Yu (Co-first Author), Feng Jiang, Junwei Zhou, Yongshu Li, Chao   Liang, Lei Dang, Ai-Ping Lu(Corresponding author) andGe Zhang(Corresponding   author). Development of cell-SELEX technology and its application in cancer   diagnosis and therapy. Int. J. Mol. Sci.


Lv H, Jiang F,   Guan D, Lu C, Guo B, Chan C, Peng S, Liu B, Guo W, Zhu H, Xu X (Corresponding   Author),Lu A   (Corresponding Author), Zhang G (Corresponding Author). Metabolomics and its application in   the development of discovering biomarkers for osteoporosis research. Int. J.   Mol. Sci. 2016, 17(12), 2018.


Bing He,   Zong-Kang Zhang, Jin Liu, Yi-Xin He, Tao Tang, Jie Li, Bao-Sheng Guo, Ai-Ping Lu(Corresponding   author), Bao-Ting Zhang,and Ge Zhang(Corresponding author). Bioinformatics and Microarray   Analysis of miRNAs in Aged Female Mice Model Implied New Molecular Mechanisms   for Impaired Fracture Healing. Int. J. Mol. Sci. 2016, 17(8),   1260.


Yongshu Li,   Fangfei Li, Feng Jiang, Xiaoqing Lv, Rongjiang Zhang, Aiping Lu(Corresponding author), and   Ge Zhang(Corresponding author). A Mini-Review for Cancer Immunotherapy: Molecular   Understanding of PD-1/PD-L1 Pathway & Translational Blockade of Immune   Checkpoints. Int. J. Mol. Sci. 2016, 17, 1151.


Bing He, Cheng   Lu, Guang Zheng, Xiaojuan He, Maolin Wang, Gao ChenGe Zhang (Corresponding author), Aiping   Lu (Corresponding author). Combination therapeutics in complex diseases. J.   Cell. Mol. Med. 2016.


Meng, Z.   (Co-first author); Lv, Q. (Co-first author); Lu, J.; Yao, H.; Lv, X.;  Jiang, F. (Corresponding   author); Lu, A. (Corresponding author); Zhang, G. (Corresponding   author). Prodrug Strategies for Paclitaxel. Int. J. Mol. Sci. 2016,   17, 796.


Wang, M.; Yu,   Y.; Liang, C.; Lu A (Corresponding author), Zhang G (Corresponding   author). Recent   Advances in Developing Small Molecules Targeting Nucleic Acid. Int.   J. Mol. Sci. 2016, 17, 779.


Wang LY   (co-first author), Li FF (co-first author), Dang L (co-first author), Liang   C, Wang C, He B, Liu J, Li DF, Wu XH, Xu XG (Corresponding author), Lu AP (Corresponding author), Zhang G   (Corresponding author). In Vivo Delivery Systems for Therapeutic Genome   Editing. Int. J. Mol. Sci. 2016.


Lu J, Jiang F, Lu A (Corresponding author), Zhang G   (Corresponding author). Linkers Having a Crucial Role in Antibody–Drug   Conjugates. Int. J. Mol. Sci. 2016, 17(4): 561.


Fan DP   (Co-first author), He XJ (Co-first author), Bian YQ, Guo QQ, Zheng K, Zhao   YK, Lu C, Liu BQ,Xu XG (Corresponding author), Lu A (Corresponding   author), Zhang G (Corresponding author).Triptolide modulates TREM-1 signal   pathway to inhibit inflammatory response in rheumatoid arthritis. Int.   J. Mol. Sci. 2016, 17(4): 498.


Shaikh AB   (Co-first Author), Li FF (Co-first Author) , Li M (Co-first Author), He B   (Co-first Author), He XJ, Chen GF, Guo BS, Li DF, Jiang F, Dang L, Zheng SW,   Liang C, Liu J, Lu C, Liu B, Lu J, Wang LY,  Lu A(Corresponding author), Zhang G (Corresponding   author). Present   Advances and Future Perspectives of Molecular Targeted Therapy for   Osteosarcoma. Int. J. Mol. Sci. 2016, 17(4): 506.


Wu XH (Co-first Author), He B (Co-first Author), Liu J (Co-first Author), Feng H (Co-first Author), Ma YH, Li DF, Guo BS, Liang C, Dang   L, Wang LY, Tian J,  Zhu HL (Corresponding author), Xiao LB (Corresponding   author), Lu C (Corresponding author), Lu A (Corresponding author), Zhang G   (Corresponding author). Molecular Insight into Gut Microbiota and Rheumatoid   Arthritis. Int. J. Mol. Sci. 2016, 17(3): 431.


Dang L (Co-first Author), Liu J (Co-first Author), Li FF (Co-first Author), Wang LY (Co-first Author), Li DF, Guo BS, He XJ, Jiang F, Liang   C, LiuB, Shaikh AB, He B, Lu J, Lu C, Lu A (Corresponding author), Zhang G   (Corresponding author). Targeted delivery systems for molecular therapy in   skeletal disorders. Int. J. Mol. Sci. 2016.


Yu YY, Liang   C, Lv QX, Li DF, Xu XG, Liu BQ (Corresponding author), Lu A (Corresponding author), Zhang G (Corresponding   author). Molecular   Selection, Modification and Development of Therapeutic Oligonucleotide   Aptamers. Int. J. Mol. Sci. 2016, 17(3): 358.


Zhou W, Wang   Y,  Lu A   (Corresponding Author), Zhang G (Corresponding Author). Systems Pharmacology in Small   Molecular Drug Discovery. Int. J. Mol. Sci. 2016; 17(2):   246.


Yao HZ, Jiang   F, Lu A   (Corresponding Author), Zhang G (Corresponding Author). Methods to Design and Synthesize   Antibody-Drug Conjugates (ADCs). Int. J. Mol. Sci. 2016,   17(2): 194.


Jiang F   (Co-first Author), Liu B (Co-first Author), Lu J (Co-first Author), Li F   (Co-first Author), Li D, Liang C, Dang L, Liu J, He B, Badshah S A, Lu C, He   X, Guo B, Zhang X-B (Corresponding Author), Tan W (Corresponding Author), Lu A (Corresponding Author), Zhang G   (Corresponding Author).Progress and Challenges in Developing   Aptamer-Functionalized Targeted Drug Delivery Systems. Int. J. Mol.   Sci. 2015 Oct 16(10): 23784-23822.


Protein Kinase   C Inhibitor, GF109203X Attenuates Osteoclastogenesis, Bone Resorption and   RANKL-induced NF-κB and NFAT activity. Yao J, Li J, Zhou L, Cheng J, Chim SM,   Zhang G, Quinn JM,Tickner J, Zhao J, Xu J.J Cell Physiol. 2014 Nov 3. doi:   10.1002/jcp.24858.


Sheng H, Rui   XF, Sheng CJ, Li WJ, Cheng XY, Jhummon NP, Yu YC, Qu S, Zhang G, Qin L.A novel semisynthetic   molecule icaritin stimulates osteogenic differentiation and inhibits   adipogenesis of mesenchymal stem cells. Int J Med Sci. 2013;10:   782-9


Shanthanagouda   AH, Guo BS, Ye RR, Liang C, Chiang WL, Singaram G, Cheung KM, Zhang G (Corresponding author), Au WT (Corresponding author).Japanese Medaka: A Non-Mammalian Vertebrate Model for Studying Sex and   Age-Related Bone Metabolism in vivo. PLoS One. 2014 Jan   5;9(2):e88165.


Zheng LZ, Liu   Z, Lei M, Peng J, He YX, Xie XH, Man CW, Huang L, Wang XL, Fong DT, Xiao DM,   Wang DP, Chen Y, Feng JQ, Liu Y, Zhang G (Corresponding author),Qin L (Corresponding author).   Steroid-associated hip joint collapse in bipedal emus.PLoS One. 2013   Oct 21;8(10):e76797.


Liu B, Zhang   H, Li J, Lu C, Chen G, Zhang G, Lu A, He X. Triptolide downregulates Treg cells and the   level of IL-10, TGF-β, and VEGF in melanoma-bearing mice. Planta Med.   2013 Oct;79(15):1401-7.


Jiang M, Chen   T, Feng H, Zhang Y, Li L, Zhao A, Niu X, Liang F, Wang M, Zhan J, Lu C, He X,   Xiao L, Jia W, Lu A.Serum metabolic signatures of four types of human   arthritis. J Proteome Res. 2013 Aug 2;12(8):3769-79. doi:   10.1021/pr400415a.


Guo B, Zhang   B, Zheng L, Tang T, Liu J, Wu H, Yang Z, Peng S, He X, Zhang H, Yue KK, He F,   Zhang L, Qin L, Bian Z, Tan W, Liang Z, Lu A, Zhang G. Therapeutic RNA interference   targeting CKIP-1 with a cross-species sequence to stimulate bone formation. Bone.   2013;59:76-88.


Peng S, Zhang G (Co-first author), Zhang BT, Guo B, He Y, Bakker AJ,   Pan X, Zhen W, Hung L, Qin L, Leung WN. The Beneficial Effect of Icaritin on   Osteoporotic Bone is Dependent on the Treatment Initiation Timing in Adult   Ovariectomized Rats. Bone. 2013 Feb 25. [Epub ahead of print]


Yang Z, Lu A,   Wong BC, Chen X, Bian Z, Zhao Z, Huang W, Zhang G, Chen H, Xu M. Effect of Liposomes on   the Absorption of Water-Soluble Active Pharmaceutical Ingredients Via Oral   Administration. Curr Pharm Des. 2013 Apr 23. [Epub ahead of   print]


Wang XL, Xie   XH, Zhang G, Chen SH, Yao D, He K, Wang XH, Yao   XS, Leng Y, Fung KP, Leung KS, Qin L.. Exogenous phytoestrogenic molecule   icaritin incorporated into a porous scaffold for enhancing bone defect   repair. J Orthop Res. 2013 Jan;31(1):164-7.


Xu Q, Bauer R,   Hendry BM, Fan TP, Zhao Z, Duez P, Simmonds MS, Witt CM, Lu A, Robinson N, Guo DA, Hylands PJ.The   quest for modernisation of traditional Chinese medicine. BMC   Complement Altern Med. 2013 Jun 13;13:132.


Liang F, Li L,   Wang M, Niu X, Zhan J, He X, Yu C, Jiang M, Lu A (Corresponding Author). Molecular network and chemical   fragment-based characteristics of medicinal herbs with cold and hot   properties from Chinese medicine. J Ethnopharmacol. 2013 May 20.


Wang LY, Chan   KW, Yuwen Y, Shi NN, Han XJ, Lu A (Corresponding Author). Expert consensus on the treatment of   hypertension with chinese patent medicines. Evid Based Complement   Alternat Med. 2013;2013:510146.


Dai J, Fang J,   Sun S, Chen Q, Cao H, Zheng N, Zhang Y, Lu A.ZHENG-Omics Application in ZHENG Classification   and Treatment: Chinese Personalized Medicine. Evid Based Complement   Alternat Med. 2013;2013:235969.


Yang Z, Lu A, Wong BC, Chen X, Bian Z, Zhao Z,   Huang W, Zhang G, Chen H, Xu M. Effect of Liposomes on the Absorption of   Water-Soluble Active Pharmaceutical Ingredients Via Oral Administration. Curr   Pharm Des. 2013 Apr 23. [Epub ahead of print]


Liu C, Zhang   Y, Kong X, Zhu L, Pang J, Xu Y, Chen W, Zhan H, Lu A, Lin N.  Triptolide Prevents Bone   Destruction in the Collagen-Induced Arthritis Model of Rheumatoid Arthritis   by Targeting RANKL/RANK/OPG Signal Pathway. Evid Based Complement   Alternat Med. 2013;2013:626038. doi: 10.1155/2013/626038.


Lu C, Liu X,   Ding X, Chen X, Fan H, Liu Y, Xie N, Tan Y, Ko J, Zhang W, Lu A (Corresponding Author). A Metabolomics Profiling Study in   Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention   Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry. Evid   Based Complement Alternat Med. 2013; 2013:647452.


Zha Q, Lin S,   Zhang C, Chang C, Xue H, Lu C, Jiang M, Liu Y, Xiao Z, Liu W, Shang Y, Chen   J, Wen M, Lu A (Corresponding Author). Xiaoqinglong granules as add-on therapy for asthma:   latent class analysis of symptom predictors of response. Evid Based   Complement Alternat Med. 2013;2013:759476. doi:   10.1155/2013/759476.


Li X, Zhang C,   Shi Q, Yang T, Zhu Q, Tian Y, Lu C, Zhang Z, Jiang Z, Zhou H, Wen X, Yang H,   Ding X, Liang L, Liu Y, Wang Y,Lu A (Corresponding Author). Improving the efficacy of   conventional therapy by adding and rographolide sulfonate in the treatment of   severe hand, foot, and mouth disease: a randomized controlled trial. Evid Based Complement Alternat Med.2013;2013:316250.   doi:10.1155/2013/316250.


Xie XH, Wang   XL, Zhang G, He YX, Leng Y, Tang TT, Pan X, Qin   L.. Biofabrication of a PLGA-TCP-based porous bioactive bone substitute with   sustained release of icaritin. J Tissue Eng Regen Med. 2012 Dec   18.


Baosheng Guo, Songlin   Peng, Chao Liang, Xiaojuan He, Cheng Xiao, Cheng Lu, Miao Jiang, Hongyan   Zhao, Aiping Lu (Corresponding Author), Ge Zhang (Corresponding Author).Recent developments in bone anabolic   therapy for osteoporosis.Expert Review of Endocrinology & Metabolism.   2012 Nov;7(6): 677-685


Zhu GY, Wong   BC, Lu A, Bian ZX, Zhang G, Chen HB, Wong YF, Fong WF, Yang Z. Alkylphenols from   the roots of Ardisia brevicaulis induce G1 arrest and apoptosis through   endoplasmic reticulum stress pathway in human non-small-cell lung cancer   cells. Chem Pharm Bull (Tokyo). 2012;60(8):1029-36.


Wei F, Moore   DC, Li Y, Zhang   G, Wei X, Lee   JK, Wei L. Attenuation of osteoarthritis via blockade of the SDF-1/CXCR4   signaling pathway. Arthritis Res Ther. 2012 Jul 31;14(4):R177.


Zhu HM   (Co-first author), Qin L (Co-first author), Garnero P (Co-first author),   Genant HK (Co-first author), Zhang G(Co-first author), Dai K, Yao X, Gu G, Hao Y, Li Z,   Zhao Y, Li W, Yang J, Zhao X, Shi D, Fuerst T, Lu Y, Li H, Zhang X, Li C,   Zhao J, Wu Q, Zhao SJ.The first multicenter and randomized clinical trial of   herbal Fufang for treatment of postmenopausal osteoporosis.Osteoporos Int.   2012 Apr;23(4):1317-27.


He YX, Liu Z,   Pan XH, Tang T, Guo BS, Zheng LZ, Xie XH, Wang XL, Lee KM, Li G, Cao YP, Wei   L, Chen Y, Yang ZJ, Hung LK, Qin L, Zhang G (Corresponding Author). Deletion of estrogen receptor beta   accelerates early stage of bone healing in a mouse osteotomy model. Osteoporos   Int. 2012 Jan;23(1):377-89.


Li J, Lu C,   Jiang M, Niu X, Guo H, Li L, Bian Z, Lin N, Lu A (Corresponding Author). Traditional chinese medicine-based   network pharmacology could lead to new multicompound drug discovery. Evid   Based Complement Alternat Med. 2012;2012:149762.


Yang H, Yang   J, Wen Z, Zha Q, Nie G, Huang X, Zhang C, Lu A (Corresponding Author), Jiang M, Wang X.Effect of combining   therapy with traditional chinese medicine-based psychotherapy and herbal   medicines in women with menopausal syndrome: a randomized controlled clinical   trial. Evid Based Complement Alternat Med. 2012;   2012:354145.


Jiang M, Lu C,   Chen G, Xiao C, Zha Q, Niu X, Chen S, Lu A (Corresponding Author).  Understanding the molecular   mechanism of interventions in treating rheumatoid arthritis patients with   corresponding traditional chinese medicine patterns based on bioinformatics   approach. Evid Based Complement Alternat Med. 2012;2012:129452.


Zhang Z, Niu   X, Lu C, Jiang M, Xiao GG, Lu A (Corresponding Author). The effect of curcumin on human   bronchial epithelial cells exposed to fine particulate matter: a predictive   analysis. Molecules. 2012 Oct 22;17(10):12406-26.


Shi N, Han X,   Yu W, Wang L, Lu A (Corresponding Author).Adoption in China of Clinical   Practice Guidelines for hypertension using Traditional Chinese Medical   approaches: a literature review based on clinical studies. J Altern   Complement Med. 2013 Jan;19(1):1-8.


Su SB, Lu A, Li S, Jia W. Evidence-Based ZHENG: A Traditional Chinese Medicine Syndrome. Evid Based Complement Alternat   Med. 2012;2012:246538.


Zhao J, Zha Q,   Jiang M, Cao H, Lu A (Corresponding Author). Expert consensus on the treatment of   rheumatoid arthritis with Chinese patent medicines. J Altern   Complement Med. 2013 Feb;19(2):111-8.


Zhu GY, Wong   BC, LuA, Bian ZX, Zhang G, Chen HB, Wong YF,   Fong WF, Yang Z.Alkylphenols from the roots of Ardisia brevicaulis induce G1   arrest and apoptosis through endoplasmic reticulum stress pathway in human   non-small-cell lung cancer cells. Chem Pharm Bull (Tokyo). 2012;60(8):1029-36


Li X, He X,   Liu B, Xu L, Lu C, Zhao H, Niu X, Chen S, Lu A (Corresponding Author). Maturation of murine bone   marrow-derived dendritic cells induced by Radix Glycyrrhizae polysaccharide. Molecules.   2012 May 30;17(6):6557-68.


Jiang M, Zhang   C, Zheng G, Guo H, Li L, Yang J, Lu C, Jia W, Lu A (Corresponding Author). Traditional chinese medicine zheng   in the era of evidence-based medicine: a literature analysis. Evid   Based Complement Alternat Med. 2012;2012:409568. doi:   10.1155/2012/409568.


Guo DA, Lu A, Liu L.Modernization of traditional   Chinese medicine. J Ethnopharmacol. 2012 Jun   1;141(2):547-8.


Zhao H, Li J,   He X, Lu C, Xiao C, Niu X, Zhao N, Ju D, Lu A (Corresponding Author). The protective effect of yi shen   juan bi pill in arthritic rats with castration-induced kidney deficiency. Evid   Based Complement Alternat Med.2012;2012:102641.


Lu C, Niu X,   Xiao C, Chen G, Zha Q, Guo H, Jiang M, Lu A (Corresponding Author). Network-based gene expression   biomarkers for cold and heat patterns of rheumatoid arthritis in traditional   chinese medicine. Evid Based Complement Alternat Med. 2012;2012:203043.


Gu Y, Lu C,   Zha Q, Kong H, Lu X, Lu A (Corresponding Author), Xu G.Plasma metabonomics study of   rheumatoid arthritis and its Chinese medicine subtypes by using liquid   chromatography and gas chromatography coupled with mass spectrometry.Mol   Biosyst. 2012 Apr;8(5):1535-43.


He X, Shu J,   Xu L, Lu C, Lu A (Corresponding Author). Inhibitory effect of Astragalus   polysaccharides on lipopolysaccharide-induced TNF-a and IL-1β production in   THP-1 cells. Molecules. 2012 Mar 12;17(3):3155-64.


Chan K, Shaw   D, Simmonds MS, Leon CJ, Xu Q, Lu A, Sutherland I, Ignatova S, Zhu YP,   Verpoorte R, Williamson EM, Duez P.Good practice in reviewing and publishing   studies on herbal medicine, with special emphasis on traditional Chinese   medicine and Chinese materia medica. J Ethnopharmacol. 2012   Apr 10;140(3):469-75.


Jiang M, Lu C,   Zhang C, Yang J, Tan Y, Lu A (Corresponding Author), Chan K. Syndrome differentiation in   modern research of traditional Chinese medicine. J Ethnopharmacol.   2012 Apr 10; 140(3):634-42.


Wang X, Zhen   L, Zhang G, Wong MS, Qin L, Yao X. Osteogenic   effects of flavonoid aglycones from an osteoprotective fraction of Drynaria   fortunei--an in vitro efficacy study. Phytomedicine. 2011 Jul   15;18(10):868-72.


He YX, Zhang G (Corresponding Author), Pan XH, Liu Z, Zheng LZ, Chan CW,   Lee KM, Cao YP, Li G, Wei L, Hung LK, Leung KS, Qin L(Corresponding Author).Impaired bone healing pattern in mice with ovariectomy-induced osteoporosis:   A drill-hole defect model. Bone. 2011 Jun 1;48(6):1388-400.


Xie XH, Wang   XL, Zhang G, Liu Z, Yao D, Hung LK, Hung VW, Qin   L.Impaired bone healing in rabbits with steroid-induced osteonecrosis. J   Bone Joint Surg Br. 2011 Apr;93(4):558-65.


Tang T   (Co-first author), Zhang G (Co-first author), Lau CP, Zheng LZ, Xie XH, Wang XL,   Wang XH, He K, Patrick Y, Qin L, Kumta SM. Effect of water-soluble P-chitosan   and S-chitosan on human primary osteoblasts and giant cell tumor of bone   stromal cells. Biomed Mater. 2011 Feb;6(1):015004.


Zheng G, Jiang   M, He X, Zhao J, Guo H, Chen G, Zha Q, Lu A (Corresponding Author). Discrete derivative: a data slicing   algorithm for exploration of sharing biological networks between rheumatoid   arthritis and coronary heart disease.BioData Min. 2011 Jun 23;4:18.


Jiang M, Xiao   C, Chen G, Lu C, Zha Q, Yan X, Kong W, Xu S, Ju D, Xu P, Zou Y, Lu A (Corresponding Author). Correlation between cold and hot   pattern in traditional Chinese medicine and gene expression profiles in   rheumatoid arthritis.Front Med. 2011 Jun;5(2):219-28.


Liu Z, Liu Y,   Wang C, Guo N, Song Z, Wang C, Xia L, Lu A (Corresponding Author). Comparative analyses of   chromatographic fingerprints of the roots of Polygonum multiflorum Thunb. and   their processed products using RRLC/DAD/ESI-MS(n). Planta Med.   2011 Nov;77(16):1855-60.


Xiao C, Li J,   Dong X, He X, Niu X, Liu C, Zhong G, Bauer R, Yang D, Lu A (Corresponding Author). Anti-oxidative and TNF-α suppressive   activities of puerarin derivative (4AC) in RAW264.7 cells and   collagen-induced arthritic rats. Eur J Pharmacol. 2011   Sep;666(1-3):242-50.


Jiang M, Zha   Q, Lu C, He Y, Lu A (Corresponding Author). Association between tongue   appearance in Traditional Chinese Medicine and effective response in   treatment of rheumatoid arthritis. Complement Ther Med. 2011   Jun;19(3):115-21.


Zhang C, Jiang   M, Lu A   (Corresponding Author). traditional Chinese medicine versus Western   combination therapy in the treatment of rheumatoid arthritis: two-stage study   protocol for a randomized controlled trial. Trials. 2011 Jun   4;12:137.


Jiang M, Zhang   C, Cao H, Chan K, Lu A (Corresponding Author).The role of Chinese medicine in the   treatment of chronic diseases in China. P lanta Med. 2011   Jun;77(9):873-81.


Li J, Lu Y,   Xiao C, Lu C, Niu X, He X, Zhao H, Tan Y, Lu A (Corresponding Author).Comparison of toxic reaction of   Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. Ethnopharmacol. 2011   May 17;135(2):270-7.


Liu Z, Liu Y,   Chao Z, Song Z, Wang C, Lu A (Corresponding Author). In vitro antioxidant activities of   maillard reaction products produced in the steaming process of Polygonum   multiflorum root. Nat Prod Commun. 2011 Jan;6(1):55-8.


Song XS, Zhou   XZ, Zhang G, Dong QR, Qin L.Low-dose X-ray   irradiation promotes fracture healing through up-regulation of vascular   endothelial growth factor. Med Hypotheses. 2010 Dec;75(6):522-4.


Xie XH, Wang   XL, Zhang G, He YX, Wang XH, Liu Z, He K, Peng J,   Leng Y, Qin L.Structural and degradation characteristics of an innovative   porous PLGA/TCP scaffold incorporated with bioactive molecular icaritin. Biomed   Mater. 2010 Oct;5(5):054109.


Wang XL, Wang   NL, Gao H, Zhang G, Qin L, Wong MS, Yao XS.Phenylpropanoid and   flavonoids from osteoprotective fraction of Drynaria fortunei. Nat   Prod Res. 2010 Aug;24(13):1206-13.


Zhang P, Qin   L, Zhang   G. The   potential application of nicotinic acetylcholine receptor agonists for the   treatment of rheumatoid arthritis. Inflamm Res. 2010   Jun;59(6):415-7.


Qin L, Wang L,   Wong MW, Wen C, Wang G, Zhang G, Chan KM, Cheung WH, Leung KS.Osteogenesis Induced by   Extracorporeal Shockwave in Treatment of Delayed Osteotendinous Junction   Healing. J Orthop Res. 2010 Jan;28(1):70-6.


Liang Z, Zhu   X, Yang X, Fu W, Lu A. Assessment of a traditional acupuncture therapy for   chronic neck pain: a pilot randomised controlled study. Complement   Ther Med. 2011 Jan;19 Suppl 1:S26-32.


Ma W, Bai W,   Lin C, Zhou P, Xia L, Zhao C, Hao Y, Ma H, Liu X, Wang J, Yuan H, Xie Y, Lu A. Effects of Sanyinjiao (SP6) with   electroacupuncture on labour pain in women during labour. Complement   Ther Med. 2011 Jan;19 Suppl 1:S13-8.


Jiang M, Yang   J, Zhang C, Liu B, Chan K, Cao H, Lu A (Corresponding Author). Clinical studies with traditional   Chinese medicine in the past decade and future research and development. Planta   Med. 2010 Dec;76(17):2048-64.


Zhao N, Zhang   W, Guo Y, Jia H, Zha Q, Liu Z, Xu S, Lu A (Corresponding Author). Effects on neuroendocrinoimmune   network of Lizhong Pill in the reserpine induced rats with spleen deficiency   in traditional Chinese medicine. J Ethnopharmacol. 2011 Jan   27;133(2):454-9.


Wang HH, Wang   YX, Griffith JF, Sun YL, Zhang G, Chan CW, Qin L, Ahuja AT, Teng LS.Pitfalls in   interpreting rat knee joint magnetic resonance images and their histological   correlation. Acta Radiol. 2009 Nov;50(9):1042-8


Peng S   (Co-first author), Zhang G (Co-first author), He Y, Wang X, Leung P, Leung K, Qin   L. Epimedium-derived flavonoids promote osteoblastogenesis and suppress   adipogenesis in bone marrow stromal cells while exerting an anabolic effect   on osteoporotic BOBone. 2009 Sep;45(3):534-44.


Zhang G, Wang XL, Sheng H, Xie XH, He YX, Yao   XS, Li ZR, Lee KM, He W, Leung KS, Qin L.Constitutional flavonoids derived   from Epimedium dose-dependently reduce incidence of steroid-associated   osteonecrosis not via direct action by themselves on potential cellular   targets. PLoS One. 2009 Jul 29;4(7):e6419.


Sheng H, Zhang G, Wang YX, Yeung DK, Griffith JF,   Leung KS, Qin L.Functional perfusion MRI predicts later occurrence of   steroid-associated osteonecrosis: an experimental study in rabbits. J   Orthop Res. 2009 Jun;27(6):742-7.


Wang HH, Wang   YX, Sheng H, Zhang G, Qin L, Ahuja AT, Teng LS.Fossa trochanterica of the   proximal femur in rabbits: an anatomic structure for potential   misinterpretation on magnetic resonance images. Acta Radiol. 2009   Mar;50(2):212-6.


Zhang G, Qin L, Sheng H, Wang XL, Wang YX,   Yeung DK, Griffith JF, Yao XS, Xie XH, Li ZR, Lee KM, Leung KS.A novel   semisynthesized small molecule icaritin reduces incidence of   steroid-associated osteonecrosis with inhibition of both thrombosis and   lipid-deposition in a dose-dependent manner. Bone. 2009   Feb;44(2):345-56.


Zhou XZ, Zhang G, Dong QR, Chan CW, Liu CF, Qin L. Low-dose X-irradiation promotes mineralization of fracture callus in a rat   model. Arch Orthop Trauma Surg. 2009 Jan;129(1):125-32.


Qin L, Zhang G, Sheng H, Wang XL, Wang YX, Yeung KW,   Griffith JF, Li ZR, Leung KS, Yao XS. Phytoestrogenic compounds for   prevention of steroid-associated osteonecrosis. J Musculoskelet   Neuronal Interact. 2008 Jan-Mar;8(1):18-21.


Wang XL, Wang   NL, Zhang Y, Gao H, Pang WY, Wong MS, Zhang G, Qin L, Yao XS. Effects of eleven   flavonoids from the osteoprotective fraction of Drynaria fortunei (KUNZE) J.   SM. on osteoblastic proliferation using an osteoblast-like cell line.Chem   Pharm Bull (Tokyo). 2008 Jan;56(1):46-51.


Zhang G, Qin L, Sheng H, Yeung KW, Yeung HY,   Cheung WH, Griffith J, Chan CW, Lee KM, Leung KS. Epimedium-derived   phytoestrogen exert beneficial effect on preventing steroid-associated   osteonecrosis in rabbits with inhibition of both thrombosis and   lipid-deposition. Bone. 2007 Mar;40(3):685-92.


Hao YJ, Zhang G, Wang YS, Qin L, Hung WY, Leung K,   Pei FX. Changes of microstructure and mineralized tissue in the middle and   late phase of osteoporotic fracture healing in rats. Bone. 2007   Oct;41(4):631-8.


Qin L, Zhang G, Sheng H, Yeung KW, Yeung HY, Chan   CW, Cheung WH, Griffith J, Chiu KH, Leung KS. Multiple bioimaging modalities   in evaluation of an experimental osteonecrosis induced by a combination of   lipopolysaccharide and methylprednisolone. Bone. 2006   Oct;39(4):863-71.


Zhang G, Qin L, Hung WY,Shi YY, Leung PC,   Yeung HY, Leung KS. Flavonoids derived from herbal Epimedium Brevicornum   Maxim prevent OVX-induced osteoporosis in rats independent of its enhancement   in intestinal calcium absorption.Bone. 2006 Jun;38(6):818-25.


Zhang G   (Corresponding Author), Qin L, Shi Y, Leung K.A comparative study between   axial compression and lateral fall configuration tested in a rat proximal   femur model. Clin Biomech(Bristol, Avon). 2005 Aug;20(7):729-35.


Qin L, Zhang G, Hung WY, Shi Y, Leung K, Yeung HY,  Leung P. Phytoestrogen-rich herb formula "XLGB" prevents  OVX-induced deterioration of musculoskeletal tissues at the hip in old rats. J   Bone Miner Metab. 2005;23. Suppl:55-61.





























































































































































































































Zheng LZ, Cao   HJ, Chen SH, Tang T, Fu WM, Huang L, Chow DH, Wang YX, Griffith JF, He W,   Zhou H, Zhao W,Zhang G(Corresponding Author), Wang XL, Qin L. Blockage of Src by Specific siRNA as a   Novel Therapeutic Strategy to Prevent Destructive Repair in   Steroid-Associated Osteonecrosis in Rabbits. J Bone Miner Res. 2015 Apr 27. doi: 10.1002/jbmr.2542.

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