Note: TMBJ academic staffs’ name are highlighted with blue.

 

Published Conference Abstract in 2017

 

1.         

Yu Y, Li Y, Wu X, Li F, Lu A, Zhang G. An innovative gain-loss cell-SELEX strategy for development of a nucleic acid aptamer against PD-L1 for immunotherapy of triple negative breast cancer. Aptamer 2017, 11-12 April 2017. Oxford, UK.

2.         

Liang C, Peng S, Zhang BT, Lu Aiping, Zhang G. From precision medicine to drug discovery: inhibition of osteoblastic Smurf1 promotes bone formation in distinctive individuals with age-related osteoporosis. 2017 ICMRS-ORS Membership Meeting, March 20, 2017. San Diego, California, USA.

3.         

Liang C, Peng S, Zhang BT, Lu Aiping, Zhang G. From precision medicine to drug discovery: inhibition of osteoblastic Smurf1 promotes bone formation in distinctive individuals with age-related osteoporosis. 2017 ORS Annual Meeting, March 19-22, 2017. San Diego, California, USA.

4.         

Liu J, Wu X, Lu A, Zhang G. Elevated osteoclastic miR-214-3p targets TIMP2 to promote subchondral bone remodeling in early osteoarthritis. OARSI 2017 World Congress on Osteoarthritis, April 27 ­ 30, 2017. Las Vegas, Nevada, USA.

 

 

Published Conference Abstract in 2016

 

1.         

Yu Y, Liang C, Lv Q, Li D, Xu X, Liu   B, Lu A, Zhang G. Molecular Selection, Modification and   Development of Therapeutic Oligonucleotide Aptamers. Aptamers 2016, Oxford,   April 4-5, 2016.

2.         

Wu X.H., Liu J, Xiao L.B., Lu A.P., Zhang G. Alterations of gut microbiome in rheumatoid arthritis. Oral Abstract.   Webster Jee Travel Award, the 8th International   Conference on   Osteoporosis and Bone Research, 19-22 October, 2016, Chong   Qing,   China.

3.         

Wang L.Y.,   Liang C, Li F.F., Zhang G, Lu A.P. Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized   lipopolymer for therapeutic genome editing of VEGF-A in osteosarcoma. Oral   Abstract. Webster Jee Travel Award, the 8th International Conference on   Osteoporosis and Bone Research, 19-22 October, 2016, Chong Qing, China.

4.         

Liang C, Peng   S, Zhang BT, Lu Aiping, Zhang G. Inhibition of osteoblastic Smurf1 promotes bone formation in   distinctive individuals with age-related osteoporosis. Oral Abstract. 8th   International Conference on Osteoporosis and Bone Research, October 19-22,   2016, Chongqing, China.

 

 

 

Published Conference Abstract in 2015

 

5.         

Guo B, Lu A, Zhang B, Zhang G. Therapeutic inhibition of miR-214 by   (AspSerSer)6-liposome encapsulating antagomir-214 in osteoblast cells for   promoting bone formation in aged osteoporotic rats. 2015 Orthopaedic Research   Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

6.         

Liang C, Guo B, Wu H, Zhang L, Lu A, Zhang G. Aptamer-functionalized delivery system for osteogenic siRNAs to   achieve osteoblast-specific RNA interference for bone anabolic therapy. 2015   Orthopaedic Research Society (ORS) annual meeting, Las Vegas, March 28-31,   2015.

7.         

Lv C, Liu J, Guo B, Li D, Liang C,   Zhang B, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 expression and   decreased phosphorylated Smad1/5 within osteoblasts during bone formation   reduction in glucocorticoid-induced osteoporotic rats. 2015 Orthopaedic   Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

8.         

Li D, Liu J, Guo B, Liang C, Dang L,   He X, Liang Z, Lu A, Zhang G. Exosome-encapsulated miR-214   secreted from osteoclast to inhibit osteoblastic activity. 2015 Orthopaedic   Research Society (ORS) annual meeting, Las Vegas, March 28-31, 2015.

9.         

Liu J, Guo B, Li D, Liang C, Dang L,   He X, Zhang B, Pan X, Zhang L, Lu A, Zhang G. Increased CKIP-1 within osteoblast suppress BMP signaling to inhibit   bone formation during aging. 2015 Orthopaedic Research Society (ORS) annual   meeting, Las Vegas, March 28-31, 2015.

10.      

Dang L, Guo B, Li D, Liu J, Liang C,   He X, Wu H, Yang Z, Liang Z, Lu A, Zhang G. Adelivery system approach bone resorption surface for specifically   targeting osteoclasts in vivo. 2015 Orthopaedic Research Society (ORS) annual   meeting, Las Vegas, March 28-31, 2015. 

11.      

Li D, Liu J, Guo B, Dang L, Liang C,   He X, Lu A, Zhang G. Elevated miR-214 level within   osteoclasts associates with increased bone resorption in both postmenopausal   osteoporosis and osteolytic bone metastasis. American Society for Bone and   Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

12.      

Li D, Liu J, Guo B, Liang C, Dang L, Lu A, Zhang G. Osteoclast-derived exosomal miR-214 inhibits osteoblastic bone   formation. American Society for Bone and Mineral Research (ASBMR) 2015 Annual   Meeting, Seattle, October 8-12, 2015.

13.      

Liu J, Li D, Guo B, Dang L, Lu A, Zhang G. Osteoclastic miR-214 targets PTEN to increase bone resorption. American   Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle,   October 8-12, 2015.

14.      

Liu J, Lv C, Guo B, Li D, Liang C, Pan   X, Zhang L, Zhang B, Lu A, Zhang G. Highly expressed CKIP-1 inhibits BMP signaling   pathway to suppress osteogenic differentiation and mineral deposition in   osteoblast during glucocorticoid treatment in vitro. American Society for   Bone and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12,   2015.

15.      

Liu J, Zhang Z, Li J, Guo B, Zhang B, Lu A, Zhang G. Targeting CKIP-1 within osteoblast: A potential anabolic strategy for   bone formation reduction during aging? American Society for Bone and Mineral   Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

16.      

Dang L, Zhang G, Li D, Liu J, Guo B, Lu A. Targeted   inhibition of miR-214 in osteoclasts suppresses bone resorption in both   ovariectomy-induced osteoporosis and osteolytic bone metastasis in vivo.   American Society for Bone and Mineral Research (ASBMR) 2015 Annual Meeting,   Seattle, October 8-12, 2015.

17.      

Liang C, Xu M, Zhou X, Wang K, Xu J,   Zhang B, Lu A, Zhang G. Discovery of Small Molecules to   Promote BMP Signaling and Bone Formation. American Society for Bone and   Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015.

18.      

Qian A, Chen Z, Arfat Y, Hu L, Shang   P, Zhang G. Mechanical unloading sensitive   miR-138 targets MACF1 to regulate bone formation. American Society for Bone   and Mineral Research (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015

19.      

Hu L, Su P, Li R, Yin C, Yan K, Zhang G, Shang P, Qian A. A Novel Role of MACF1: Positively Regulates   Osteoblast Differentiation. American Society for Bone and Mineral Research   (ASBMR) 2015 Annual Meeting, Seattle, October 8-12, 2015

20.      

Wei Zhou, Defang Li, Jin Liu, Lu A, Zhang G.Toward blockade of cartilage breakdown in rheumatoid arthritis: Prediction   of therapeutic targets from lncRNA Hotair–mediated network modeling. RNAi China, September 12, 2015

21.      

Defang Li, Jin Liu, Lu A, Zhang G.Osteoclast-derived exosomal miR-214 inhibits osteoblastic bone formation.   RNAi China, September 12, 2015

22.      

Fangfei Li, Bing He, Chao Wang, Lu A, Zhang G.Transcriptional inhibition of miR214 for treating osteosarcoma:   controllable CRISPR/Cas9 drug and aptamer-based targeted delivery. RNAi   China, September 12, 2015

23.      

Feng Jiang, Lu A, Zhang G.Progress and challenges in developing aptamer-functionalized targeted   drug delivery systems. RNAi China, September 12, 2015

24.      

Xiaojuan He, Lu A, Zhang G.Inhibition of CKIP-1 within osteoblast promoted bone formation-mediated   reparative process in mice with collagen-induced arthritis. RNAi China, September   12, 2015

 

 

Published Conference Abstract in 2014

 

25.      

Junzhe Huang, Jun Lu, Biao Liu, Xiaojuan He, Ge Zhang, Aiping Lu. Fibroblast like synoviocytes (FLS)-specific aptamer facilitates the   conjugated-triptolide selectively targeting rheumatic joints with less   exposure to liver in rodents. 8th European Workshop on Immune-Mediated   Inflammatory Diseases. Funchal - Madeira, Portugal. November 5-7, 2014.

26.      

Xiaojuan He, Kang Zheng, Yukun Zhao, Baosheng Guo, Jin Liu, Ge Zhang, Aiping Lu. Aberrant   overexpression of CKIP-1 in osteoblast correlated with progressive bone   erosion and decreased bone formation in collagen-induced arthritis of mice.   7th International Conference on Osteoporosis and Bone Research, 2014. Xiamen,   China. October 16-19, 2014 (Accepted).

27.      

Baosheng Guo, Aiping Lu, Baoting Zhang, Ge Zhang. Inhibition of miR-214 by   (Asp-Ser-Ser)6-liposome capsulated antagomiR-214 in osteogenic cells of aged   osteoporotic rats: Quantification analysis for expression levels of miR-214,   osteocalcin mRNA and ATF4 protein in osteogenic cells. 2014 American Orthopaedics   Society Annual Meeting, New Orleans, Louisiana March 15-18   (http://www.ors.org/Transactions/60/0604.pdf).

28.      

Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous   Plekho1 for promoting bone formation in a rat model of aged postmenopausal   osteoporosis (http://www.ors.org/Transactions/60/0566.pdf). 2014 American   Orthopaedics Society Annual Meeting, New Orleans, Louisiana March 15-18.

29.      

Baosheng Guo, Jin Liu, Heng Wu, Lingqiang Zhang,   Ling Qin, Aiping Lu, Baoting Zhang, Ge Zhang. Ckip-1 in osteoblasts plays an inhibition role in bone formation in   aged male osteoporosis. MOLECULAR THERAPY. Vol. 22. Suppl.1 S39-S40. American   Society of Gene & Cell Therapy 17th Annual Meeting. Washingon, DC. May   21-24, 2014.

30.      

Baosheng Guo, Liu Jin, Dang lei, Liang Chao,   Xiaohua Pan, Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Up-regulated CKIP-1 expression within osteoblasts associates with   reduced BMP signaling and decreased bone formation during aging. 5th Sino-American   Symposium on Clinical and Translational Medicine (SAS-CTM). Beijing, China.   June 21-22, 2014.

31.      

Baosheng Guo, Liu Jin, Heng Wu, Dang lei,   Lingqiang Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous Ckip-1 for promoting bone   formation in an aged rat model of male osteoporosis. ASBMR 2014 Annual   Meeting. Houston, Texas. September 12-15, 2014.

32.      

Baosheng Guo, Liang Chao, Xiaohua Pan, Lingqiang   Zhang, Aiping Lu, Baoting Zhang, Ge Zhang. Up-regulated CKIP-1 expression within osteoblasts associates with   reduced BMP signaling and decreased bone formation during aging. 7th   International Conference on Osteoporosis and Bone Research, 2014. Xiamen,   China. October 16-19, 2014 (Accepted).

33.      

Defang Li, Chao Liang, Baosheng Guo, Jin Liu, Lei Dang, Liang Xu, Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang. DNM3   Participates in Exosome-Mediated miR-214 Transfer From Differentiating   Osteoclasts To Regulate Osteoblastic Activity: In Vitro Evidences. MOLECULAR   THERAPY. Vol. 22. Suppl.1 S158-S158. American Society of Gene & Cell   Therapy 17th Annual Meeting. Washingon, DC. May 21-24, 2014.

34.      

Defang Li, Chao Liang, Baosheng Guo, Jin Liu, Lei Dang, Liang Xu, Xiaojuan He, Zicai Liang, Aiping Lu, Ge Zhang. Exosome-encapsulated   miR-214 secreted from osteoclast to inhibit osteoblastic activity. ASBMR 2014   Annual Meeting. Houston, Texas. September 12-15, 2014 (Accepted).

35.      

Biao Liu, Xiaojuan He, Ge Zhang,   Aiping Lu. A novel triptolide-nucleolin aptamer   conjugate (TMPC001) with super antitumor activity on advanced pancreatic   cancer. Planta Med 2014; 80 - CL26 DOI: 10.1055/s-0034-1382359.

36.      

Biao Liu, Baosheng Guo, Xiaojuan He, Defang Li , Ge Zhang,   Aiping Lu. A novel Triptolide-Nucleolin aptamer   conjugate with super antitumor activity on advanced pancreatic cancer cell in   vitro. MOLECULAR THERAPY. Vol. 22. Suppl.1 S221-S221. American Society of   Gene & Cell Therapy 17th Annual Meeting. May 21-24, 2014.

37.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge   Zhang. Aptamer-Functionalized Lipid   Nanoparticles (LNPs) Targeting Osteoblasts as a Novel RNA Interference-Based   Bone Anabolic Strategy. ASBMR 2014 Annual Meeting. Houston, Texas. September   12-15, 2014 (Accepted).

38.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge   Zhang. Aptamer-Functionalized Lipid   Nanoparticles (LNPs) Targeting Osteoblasts as a Novel RNAi-Based Bone   Anabolic Strategy. 5th Sino-American Symposium on Clinical and Translational   Medicine (SAS-CTM). Beijing, China. June 21-22, 2014.

39.      

Chao Liang, Baosheng Guo, Heng Wu, Lei Dang, Zhijun Yang, Lingqiang Zhang, Aiping Lu, Ge Zhang. Development of aptamer-functionalized osteoblast-targeting lipid   nanoparticles encapsulating osteogenic siRNAs for bone anabolic therapy:   investigation of tissue-selective distribution, dose-response pattern and   persistence of gene silencing. Orthopaedic Research Society (ORS) 2014 annual   meeting. March 15-18, 2014 (http://www.ors.org/Transactions/60/1160.pdf).

40.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge   Zhang. Aptamer-functionalized lipid nanoparticles (LNPs) targeting osteoblasts   as a novel RNA interference (RNAi)-based bone anabolic strategy. The 7th   International Conference on Osteoporosis and Bone Research (ICOBR 2014). October   16-19, 2014 (Accepted).

41.      

Chao Liang, Baosheng Guo, Heng Wu, Lingqiang Zhang, Aiping Lu, Ge   Zhang. Aptamer-functionalized delivery system   for osteogenic siRNAs to achieve osteoblast-specific RNA interference for   bone anabolic therapy. Orthopaedic Research Society (ORS) 2015 annual   meeting. Xiamen, China. March 28-31, 2015 (Submitted).

42.      

Lei Dang, Baosheng Guo, Defang Li, Aiping Lv, Ge Zhang. A delivery system specifically approaching bone resorption surfaces to   facilitate therapeutic modulation of miRNAs in osteoclasts. MOLECULAR   THERAPY. Vol. 22. Suppl.1. S131-S131. American Society of Gene & Cell   Therapy (ASGCT) 2014 annual meeting, Washington, USA. May 21-24, 2014.

43.      

Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang,   Zicai Liang, Aiping lu, Ge Zhang. A peptide-modified delivery system specifically approaching bone   resorption surfaces for therapeutic modulation of miRNAs in osteoclasts.   American Society for Bone and Mineral Research (ASMBR) 2014 annual meeting,   Houston, USA, September 12-15, 2014.

44.      

Lei Dang, Baosheng Guo, Defang Li, Jin Liu, Chao Liang, Xiaojuan He, Heng Wu, Zhijun Yang, Zicai   Liang, Aiping lu, Ge Zhang. A delivery system to approache bone resorption surfaces for   specifically targeting osteoclasts in vivo. Orthopaedic Research Society   (ORS) 2015 annual meeting, Las Vegas, USA, March 24-28, 2015 (Submitted).

45.      

Jun Lu, Biao Liu, Xiaojuan He, Jie Xu,   Aiping Lu, Ge Zhang.A novel method for aptamer-triptolide conjugate linked by an acid-labile   vinyl ether bond: synthesis, characterization and pH-sensitive biological   properties of the conjugate.University Town campus of NUS, Singapore.   December 14-17, 2014.

 

 

 

Published Conference Abstract in 2013

 

1.        

Baosheng Guo, Baoting Zhang, Jun Wang, Chao Liang,   Heng Wu, Zhijun Yang, Albert H. L. Chow, Zhibo Hou, Yadong Huang, Fuchu He, Ling   Qin, Lingqiang Zhang, Zhaoxiang Bian, Aiping Lu, Ge Zhang. (Asp-Ser-Ser)6 facilitates bone anabolic siRNA specifically targeting osteogenic   cells in aged ovariectomized rats. 2013 Orthopaedics Research Society Annual Meeting.   San Antonio, Texas. January 26–29, 2013 (http://www.ors.org/Transactions/59/PS2--082/1465.html).

2.        

Baosheng Guo, Xiaogang Wang, An Hong, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic inhibition of miR-214 within   osteogenic cells in aged osteoporotic rats induced by ovariectomy for bone anabolic   strategy: Optimization of dosage and duration. Bone Joint J 2014 vol. 96-B no.   SUPP 11. 8th Combined Meeting of Orthopaedic Research Societies. San Servolo Venice,   Italy. October 13-16, 2013.

3.        

Baosheng Guo, Xiaogang Wang, An Hong, Aiping Lu, Baoting Zhang, Ge Zhang. Therapeutic silencing intra-osseous PLEKHO1   for promoting bone formation in a rat model of aged postmenopausal osteoporosis.   RNAi China, 2013. Kunshan, China. June 20-22, 2013.

4.        

Bing He, Jin Liu, Tao Tang, Baosheng Guo, Xiaohua Pan, Aiping Lu and Ge Zhang. Potential strategy regulating miRNAs to   improve impaired fracture healing in aged females: A systematic view for timing   and targets. Bone Joint J. 2014 vol. 96-B no. SUPP 11 207. 8h Combined Meeting   of Orthopaedic Research Societies. San Servolo Venice, Italy. October 13-16, 2013.

5.        

Jin Liu, Baosheng Guo, Yixin He, Xiaohua Pan, Lei Dang, Lingqiang Zhang, Aiping Lu, Ge Zhang. Could casein kinase-2   interacting protein-1 (CKIP-1) be postulated as a molecular target for promoting   aged fracture repair in females? JOURNAL OF BONE AND MINERAL RESEARCH. Vol. 28.   Suppl. 1. 2013 American Society of Bone and Mineral Research Annual Meeting. Baltimore,   Maryland, USA. October 4–7, 2013.

 

 

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