Project 1

Title: Therapeutic RNAi targeting CKIP-1 to  reverse severe postmenopausal osteoporosis

Principal Investigator: Prof. Ge Zhang (M.D.)

Funding Body: Hong Kong  General Researh Fund

Project ID: HKBU 479111

Exercise Year: 2011/2012

Approved Project Duration: 30 months

Project Fund: HK$ 920,000

Coordinator: Dr. Baosheng  Guo (Ph.D.)

Project 2

Title: Skeletal role of CK2-interating  Protein-1 in Regulating Osteoblastic Bone

          Formation:  Molecular  Mechanism and Reversing Osteoporosis

Principal Investigator: Prof. Ge Zhang (M.D.)

Funding Body: Research  Grants Council & Natural Science Foundation Council

Project ID: N_HKBU435/12

Exercise Year: 2012/2013

Approved Project Duration: 48 months

Project Fund: HK$ 753,925

Coordinator: Dr. Baosheng  Guo (Ph.D.)

Project 3

Title: Study on molecular mechanism of bone  formation reduction in aged women:

           Functional  role of  CKIP-1

Principal Investigator: Prof. Ge Zhang (M.D.)

Funding Body: Natural  Science Foundation Council

Project ID: NSFC 81272045

Exercise Year: 2012/2013

Approved Project Duration: 36 months

Project Fund: RMB 700,000

Coordinator: Dr. Baosheng  Guo (Ph.D.)

Project 4

Title: Toward a novel bone anabolic strategy  for aged postmenopausal osteoporosis:

          Inhibiting  miR-  214  inosteogenic cells for promoting bone  formation

Principal Investigator: Prof. Ge Zhang (M.D.)

Funding Body: Hong Kong  General Research Fund

Project ID: HKBU 478312

Exercise Year: 2012/2013

Approved Project Duration: 30 months

Project Fund: HK$ 950,000

Coordinator: Dr. Baosheng  Guo (Ph.D.)

 

Project 5

Title: Establishing the bridge for  translating cell-specific RNA interference to bone anabolictherapy:

          An aptamer-functionalized osteoblast-targeting delivery system for osteogenic siRNAs

Principal Investigator: Prof. Ge Zhang (M.D.)

Funding Body: Science and Technology  Innovation Commission of Shenzhen Municipality

Project ID: SCM-2013-SZTIC-001

Exercise Year: 2013/2014

Approved Project Duration: 24 months

Project Fund: RMB 300,000

Coordinator: Dr. Chao Liang (PH.D.)

Project 6

Title: Research and development of  triptolide-aptamer drug

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.)

Funding Body: National  Science and Technology Major Projects for "major New Drugs

Innovation and  Development"

Project ID: 2013ZX09301307

Exercise Year: 2013/2015

Approved Project Duration: 36 months

Project Fund: RMB 1,500,000

Coordinator: Dr. Xiaojuan  He (M.D.)

Project 7

Title: Understanding the molecular mechanism in failure of osteoblast-mediated repair

          for articular bone erosion during progressive rheumatoid arthritis:Role of casein kinase-2

          interacting protein-1in controlling osteoblast function 

Principal  Investigator: Prof. Aiping Lu  (M.D., Ph.D.)

Funding Body: Hong Kong  General Research Fund (GRF)

Project  ID:   HKBU261113

Exercise Year: 2013/2014

Approved Project  Duration: 30 months

Project Fund: HK$ 606,223

Coordinator: Dr. Chao Liang  (PH.D.)

 

Project 8

Title: Aptamer-functionalized  osteoblast-targeting delivery system for osteogenic siRNAs

          to achieve cell-specific RNA interference for bone anabolic therapy

 Principal  Investigator: Prof. Ge Zhang  (M.D.)

Funding Body: Hong Kong  General Research Fund (GRF)

Project  ID:  HKBU12102914

Exercise Year: 2014/2015

Approved Project  Duration: 36 months

Project Fund: HK$ 1,035,000

Coordinator: Dr. Chao Liang  (Ph.D.)

 

Project 9

Title: Toward Targeted Therapy In Advanced  Pancreatic Cancer: A Smart Triptolide-Nucleolin

           Aptamer Conjugate (UIM/256)

Principal  Investigator: Prof. Aiping  Lu (M.D., Ph.D.)

Funding Body: Hong Kong  Innovation and Technology Fund

Project  ID:  UIM/256

Exercise Year: 2014/2016

Approved Project  Duration: 24 months

Project Fund: HK$ 2,339,560

Coordinator: Mr. Biao Liu  (M.S.)

Project 10

Title:Toward Cell-targeted Therapeutics in Osteosarcoma: a Smart Triptolide-aptamer Conjugate

Principal Investigator: Prof. Aiping Lu (M.D., Ph.D.) and Prof. Dean Guo (Ph.D.)

Funding Body: Croucher Foundation

Project ID: Gnt#CAS14BU/CAS14201

Exercise Year: 2014/2016

Approved Project Duration: 36 months

Project Fund: HK$ 1,200,000

Coordinator: Dr. Defang Li (Ph.D.) and Dr. Chao Liang (Ph.D.)

Project 11

Title: Role of osteoclast-derived exosomal miR-214 in regulating osteoblastic bone formation

Principal Investigator: Prof. Ge Zhang  (M.D.)

Funding Body: Hong Kong  General Research Fund (GRF)

Project ID: HKBU12114416

Exercise Year: 2016/2017

Approved Project Duration: 36 months

Project Fund: HK$ 1,334,644

Coordinator: Dr.Jin Liu (Ph.D.)

Project 12

Title: Does aberrantly overexpressed CKIP-1 suppress osteoblast-mediated articular bone repair

          in inflammatory arthritis?  A collagen-induced non-human primate arthritis model

Principal  Investigator: Prof. Aiping  Lu (M.D., Ph.D.)

Funding Body: Hong Kong  General Research Fund (GRF)

Project  ID:  HKBU12122516

Exercise Year: 2016/2017

Approved Project  Duration: 30 months

Project Fund: HK$  795,400

Coordinator: Dr.Xiaojuan He (M.D.)

 

Project 13

Title: Molecular mechanisms of obesity with chinese medicine pattern of phlegm-dampness and

           its changes on hypertension

Principal  Investigator: Prof. Aiping  Lu (M.D., Ph.D.)

Funding Body: Natural  Science Foundation Council

Project  ID:  NSFC - General Program81673773

Exercise Year: 2016/2017

Approved Project  Duration: 24 months

Project Fund: RMB590,000

Coordinator:  Dr.Xiaojuan He (M.D.)

Project 14

Title: The role of osteoclastic miR-214-3p during the development of osteolytic bone metastasis of

           breast cancer

Principal  Investigator: Prof. Li Defang (Ph.D.)

Funding Body: Natural  Science Foundation Council

Project  ID:  NSFC - Young Scientists Fund8160111219

Exercise Year: 2016/2017

Approved Project  Duration: 36 months

Project Fund:  RMB190,000

Coordinator: Dr.Jin Liu (Ph.D.)

Project 15

Title: Targeting Sclerostin to Reverse Established Osteoporosis: Aptamer Characterization and

           Evaluation for Drug   Discover

Principal  Investigator: Dr.Yu Yuanyuan (Ph.D.)

Funding Body: Natural  Science Foundation Council

Project  ID:  NSFC - Young Scientists Fund81601929

Exercise Year: 2016/2017

Approved Project  Duration: 36 months

Project Fund: RMB 180,000

Coordinator: Dr.Yu Yuanyuan (Ph.D.)

Project 16

Title: Targeting Sclerostin to Reverse Established Osteoporosis: Aptamer Characterization and

           Evaluation for Drug   Discover

Principal  Investigator: Prof. Zhang Ge  (M.D.)

Funding Body: Hong Kong  Innovation and Technology Fund

Project  ID:  UIM/298

Exercise Year: 2016/2017

Approved Project  Duration: 24 months

Project Fund: HK$ 1,000,000

Coordinator: Dr.Yu Yuanyuan (Ph.D.)

 

Project 17

Title: The role of osteoclastic miR-214-3p in early osteoarthritis development

Principal Investigator: Prof. Zhang Ge (M.D.)

Funding Body: Hong Kong  General Research Fund (GRF)

Project ID: HKBU12101117

Exercise Year: 2016/2017

Approved Project Duration: 36 months

Project Fund: HK$ 871,855

Coordinator: Dr.Jin Liu (Ph.D.)

Project 18

Title: Tumor cell-targeted delivery of CRISPR/Cas9 by aptamer-functionalized lipopolymer for

           therapeutic genome editing of  VEGFA in osteosarcoma

Principal Investigator: Dr. Fangfei Li (Ph.D.)

Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality

Project ID: JCYJ20170307161659648

Exercise Year: 2017/2019

Approved Project Duration: 24 months

Project Fund: RMB 300,000

Coordinator: Dr. Fangfei Li (Ph.D.)

Project 19

Title: An innovative immuno-chemotherapy for triple-negative breast cancer: PD-L1 aptamer-paclitaxel 

          conjugate cancer

Principal  Investigator: Prof. Ge Zhang  (M.D.)

Funding Body: Science and Technology Innovation Commission of Shenzhen Municipality

Project  ID:  JCYJ20160229210357960

Exercise Year: 2016/2019

Approved Project  Duration: 36 months

Project Fund:  RMB3,000,000

Coordinator: Dr. Fangfei Li (Ph.D.)

 

Project 20

Title: Research on Efficacy and Mechanism of Pien Tze Huang in Multiple Sclerosis for New Drug

           Discovery

Principal Investigator: Dr.  Xiaojuan He (Ph.D.)

Funding Body:  Hong Kong  Innovation and Technology Fund

Project ID: UIM/310

Exercise Year: 2017/2018

Approved Project Duration: 18 months

Project Fund: HK$ 1,428,300

Coordinator: Dr. Xiaojuan He (Ph.D.)

 

 

 

  

 

 

 

 

 

  

 

 

 

  

 

 

 

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